Detailed information of TA system TA109871

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 918868..919513
• Replicon: chromosome
• Accession: NZ_CP031695
• Organism: Erwinia billingiae strain TH88

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: D0N50_RS04215
• Protein ID: WP_151036638.1
• Coordinates: 919115..919513 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D8MWF5
• Locus tag: D0N50_RS04210
• Protein ID: WP_013203646.1
• Coordinates: 918868..919134 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0N50_RS04190	915375..916103	-	729	WP_151036635.1	MurR/RpiR family transcriptional regulator	-
D0N50_RS04195	916103..916711	-	609	WP_151036636.1	HD domain-containing protein	-
D0N50_RS04200	916973..917626	+	654	WP_151036637.1	hemolysin III family protein	-
D0N50_RS04205	917667..918650	-	984	WP_013203647.1	tRNA-modifying protein YgfZ	-
D0N50_RS22875	918675..918848	+	174	WP_191907176.1	hypothetical protein	-
D0N50_RS04210	918868..919134	+	267	WP_013203646.1	FAD assembly factor SdhE	Antitoxin
D0N50_RS04215	919115..919513	+	399	WP_151036638.1	hypothetical protein	Toxin
D0N50_RS04220	919620..920138	-	519	WP_151036639.1	flavodoxin FldB	-
D0N50_RS04225	920237..921130	+	894	WP_151036640.1	site-specific tyrosine recombinase XerD	-
D0N50_RS04230	921182..921886	+	705	WP_151036641.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
D0N50_RS04235	921892..923610	+	1719	WP_151036642.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	909722..989319	79597

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-130)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15701.60 Da
• Isoelectric Point: 11.1373

>T109871 WP_151036638.1 NZ_CP031695:919115-919513 [Erwinia billingiae]
VALWHSDLRISWRAQWISLLLHGVVILALLLAPWPASFTLVWMLLLTLVVFECVRSQRRIRGREGVISLLEHQQMQWRQK
RWQICGRPWMTRQAIFLKLSSAKGEKEKLWLCRDSMDEDDWRALRQQLLTPG

Nucleotide

• Length: 399 bp

>T109871 NZ_CP031695:919115-919513 [Erwinia billingiae]
GTGGCCCTGTGGCACTCTGATTTACGGATCTCATGGCGTGCCCAGTGGATTTCTCTGTTGCTGCACGGCGTGGTGATCCT
TGCGCTGTTACTCGCACCCTGGCCTGCCAGTTTCACCCTGGTGTGGATGCTGCTGCTGACGCTGGTGGTGTTTGAATGCG
TGCGCAGCCAGCGGCGGATCCGCGGTCGTGAAGGCGTGATTTCGCTGCTTGAGCATCAGCAAATGCAGTGGCGGCAGAAG
CGCTGGCAGATTTGTGGCCGCCCGTGGATGACCCGACAGGCGATTTTCCTGAAATTAAGCTCAGCGAAAGGCGAGAAGGA
AAAACTGTGGTTGTGCCGCGACAGCATGGATGAAGACGACTGGCGGGCATTGCGTCAGCAGTTGCTGACGCCGGGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10456.90 Da
• Isoelectric Point: 4.7921

>AT109871 WP_013203646.1 NZ_CP031695:918868-919134 [Erwinia billingiae]
MDISNRARVHWACRRGMLELDIAIMPFFKFEYDTLDDNDKQQFVRLLESPDPDLFNWLMNHGEPDDAELKRIVNLIQQRN
QQRGPVAL

Nucleotide

• Length: 267 bp

>AT109871 NZ_CP031695:918868-919134 [Erwinia billingiae]
ATGGATATTAGTAACAGAGCACGGGTTCACTGGGCGTGCCGCCGTGGCATGCTTGAACTGGATATCGCCATCATGCCGTT
CTTCAAGTTTGAGTACGATACGCTGGACGACAATGACAAACAGCAGTTTGTGCGTCTGCTAGAAAGCCCCGATCCTGACC
TCTTTAACTGGCTGATGAATCACGGTGAGCCGGATGATGCTGAGCTGAAGCGGATAGTCAATTTGATCCAACAGCGAAAT
CAGCAACGTGGCCCTGTGGCACTCTGA

Structures

Antitoxin

• AlphaFold DB: D8MWF5