Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 685556..686193 Replicon chromosome
Accession NZ_CP031692
Organism Haemophilus influenzae strain P595-8370

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A0Y7JDC3
Locus tag CH556_RS03480 Protein ID WP_005659980.1
Coordinates 685556..685960 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag CH556_RS03485 Protein ID WP_005656316.1
Coordinates 685957..686193 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH556_RS03450 681115..681681 + 567 WP_005669020.1 elongation factor P -
CH556_RS03460 682033..682620 - 588 WP_005654063.1 primosomal replication protein -
CH556_RS03465 682653..684005 - 1353 WP_112088580.1 Na+/H+ antiporter family protein -
CH556_RS03470 684320..685009 - 690 WP_005654067.1 ribonuclease T -
CH556_RS03475 685083..685490 - 408 WP_005654069.1 lactoylglutathione lyase -
CH556_RS03480 685556..685960 - 405 WP_005659980.1 type II toxin-antitoxin system VapC family toxin Toxin
CH556_RS03485 685957..686193 - 237 WP_005656316.1 antitoxin Antitoxin
CH556_RS03490 686286..687011 - 726 WP_116945244.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
CH556_RS03495 687064..687582 - 519 WP_005659984.1 isoprenylcysteine carboxyl methyltransferase family protein -
CH556_RS03500 687801..689567 + 1767 WP_101160690.1 aspartate--tRNA ligase -
CH556_RS03505 689589..690062 + 474 WP_005659988.1 dihydroneopterin triphosphate diphosphatase -
CH556_RS03510 690074..690814 + 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15660.23 Da        Isoelectric Point: 8.9777

>T109860 WP_005659980.1 NZ_CP031692:c685960-685556 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T109860 NZ_CP031692:c685960-685556 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT109860 WP_005656316.1 NZ_CP031692:c686193-685957 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT109860 NZ_CP031692:c686193-685957 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JDC3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References