Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 559615..560093 Replicon chromosome
Accession NZ_CP031692
Organism Haemophilus influenzae strain P595-8370

Toxin (Protein)


Gene name VapD Uniprot ID A0A0H3PEZ5
Locus tag CH556_RS02830 Protein ID WP_005656500.1
Coordinates 559815..560093 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0K9KX05
Locus tag CH556_RS02825 Protein ID WP_012055040.1
Coordinates 559615..559806 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH556_RS02800 555194..555826 + 633 WP_162877137.1 dTMP kinase -
CH556_RS02805 555823..556806 + 984 WP_116945287.1 DNA polymerase III subunit delta' -
CH556_RS02810 556861..557643 + 783 WP_116945286.1 YchF/TatD family DNA exonuclease -
CH556_RS02815 557670..558194 + 525 WP_005652096.1 DUF1523 family protein -
CH556_RS02820 558245..559543 + 1299 WP_116945285.1 hemolysin family protein -
CH556_RS02825 559615..559806 + 192 WP_012055040.1 DUF5397 family protein Antitoxin
CH556_RS02830 559815..560093 + 279 WP_005656500.1 virulence-associated protein VapD Toxin
CH556_RS02835 560186..560716 + 531 WP_005656499.1 hypothetical protein -
CH556_RS02840 560788..562287 + 1500 WP_116945284.1 fused PTS fructose transporter subunit IIA/HPr protein -
CH556_RS02845 562289..563230 + 942 WP_116945283.1 1-phosphofructokinase -
CH556_RS02850 563232..564902 + 1671 WP_116945282.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.09 Da        Isoelectric Point: 5.7408

>T109859 WP_005656500.1 NZ_CP031692:559815-560093 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T109859 NZ_CP031692:559815-560093 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGTGTTCAACAGGCTTATACAGA
CATTGGCGCAGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAATATGAATGAAGATATGGCGA
ATCTTTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGTGCTTTTCGTATT
GAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7018.97 Da        Isoelectric Point: 3.9930

>AT109859 WP_012055040.1 NZ_CP031692:559615-559806 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDALVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT109859 NZ_CP031692:559615-559806 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGCGATGCGTTGGTGAATATCACATTATTACAATCTGGAGAAAAAGACATTTATCGCTTAT
CTCACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3PEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9KX05

References