109852

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 581513..581991 Replicon chromosome
Accession NZ_CP031691
Organism Haemophilus influenzae strain P615-8618

Toxin (Protein)


Gene name VapD Uniprot ID A0A0H3PEZ5
Locus tag CH576_RS02900 Protein ID WP_005656500.1
Coordinates 581713..581991 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag CH576_RS02895 Protein ID WP_005649350.1
Coordinates 581513..581704 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH576_RS02870 577092..577724 + 633 WP_162877188.1 dTMP kinase -
CH576_RS02875 577721..578704 + 984 WP_038440579.1 DNA polymerase III subunit delta' -
CH576_RS02880 578759..579541 + 783 WP_005659775.1 YchF/TatD family DNA exonuclease -
CH576_RS02885 579568..580092 + 525 WP_005656502.1 DUF1523 family protein -
CH576_RS02890 580143..581441 + 1299 WP_032821894.1 hemolysin family protein -
CH576_RS02895 581513..581704 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
CH576_RS02900 581713..581991 + 279 WP_005656500.1 virulence-associated protein VapD Toxin
CH576_RS02905 582084..582614 + 531 WP_162877158.1 hypothetical protein -
CH576_RS02910 582686..584185 + 1500 WP_116941740.1 fused PTS fructose transporter subunit IIA/HPr protein -
CH576_RS02915 584187..585128 + 942 WP_116941738.1 1-phosphofructokinase -
CH576_RS02920 585130..586800 + 1671 WP_005649337.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.09 Da        Isoelectric Point: 5.7408

>T109852 WP_005656500.1 NZ_CP031691:581713-581991 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T109852 NZ_CP031691:581713-581991 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAACAGGCTTATACAGA
CATTGGCGCAGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAACATGAATGAAGATATGGCGA
ATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGCGCTTTTCGTATT
GAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT109852 WP_005649350.1 NZ_CP031691:581513-581704 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT109852 NZ_CP031691:581513-581704 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGATTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3PEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References