Detailed information of TA system TA109851

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 343909..344419
• Replicon: chromosome
• Accession: NZ_CP031691
• Organism: Haemophilus influenzae strain P615-8618

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A2S9R6L1
• Locus tag: CH576_RS01705
• Protein ID: WP_038439526.1
• Coordinates: 343909..344130 (+)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: CH576_RS01710
• Protein ID: WP_050829196.1
• Coordinates: 344123..344419 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH576_RS01695	340424..340587	-	164	Protein_324	ABC transporter	-
CH576_RS01700	340853..343802	+	2950	Protein_325	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
CH576_RS01705	343909..344130	+	222	WP_038439526.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CH576_RS01710	344123..344419	+	297	WP_050829196.1	helix-turn-helix transcriptional regulator	Antitoxin
CH576_RS01715	344603..346519	+	1917	WP_116942002.1	ABC transporter ATP-binding protein	-
CH576_RS01720	346529..347065	+	537	WP_050837764.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
CH576_RS01725	347081..347632	+	552	WP_116942000.1	Sua5/YciO/YrdC/YwlC family protein	-
CH576_RS01730	347636..348442	+	807	WP_116941998.1	shikimate dehydrogenase	-
CH576_RS01735	348454..349212	+	759	WP_042601030.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (10-63)

Antitoxin

• Cro/C1-type helix-turn-helix domain (41-89)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8804.33 Da
• Isoelectric Point: 10.7588

>T109851 WP_038439526.1 NZ_CP031691:343909-344130 [Haemophilus influenzae]
VQNLLENQALFAILDGEIWELRPIRDRILFARLMDGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Nucleotide

• Length: 222 bp

>T109851 NZ_CP031691:343909-344130 [Haemophilus influenzae]
GTGCAAAATCTCCTTGAAAATCAAGCTCTTTTTGCTATTTTAGACGGTGAAATTTGGGAACTTCGCCCAATTCGGGATCG
CATCTTGTTTGCAAGATTAATGGACGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAAC
GAGAAATCCAAACTGCCCAACAACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11121.00 Da
• Isoelectric Point: 10.5623

>AT109851 WP_050829196.1 NZ_CP031691:344123-344419 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQRLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT109851 NZ_CP031691:344123-344419 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCGACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A2S9R6L1