Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 45678..46309 Replicon chromosome
Accession NZ_CP031691
Organism Haemophilus influenzae strain P615-8618

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag CH576_RS00225 Protein ID WP_005651560.1
Coordinates 45911..46309 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag CH576_RS00220 Protein ID WP_005648011.1
Coordinates 45678..45911 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH576_RS00195 41156..42358 - 1203 WP_105894712.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
CH576_RS00200 42522..43187 + 666 WP_105894713.1 DNA repair protein RadC -
CH576_RS00205 43401..43637 + 237 WP_005542826.1 50S ribosomal protein L28 -
CH576_RS00210 43649..43819 + 171 WP_005613503.1 50S ribosomal protein L33 -
CH576_RS00215 44167..45531 + 1365 WP_074039351.1 diaminobutyrate--2-oxoglutarate transaminase -
CH576_RS00220 45678..45911 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
CH576_RS00225 45911..46309 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
CH576_RS00230 46329..47864 + 1536 WP_105894714.1 L-2,4-diaminobutyrate decarboxylase -
CH576_RS00235 48097..48912 + 816 WP_005648023.1 DNA-formamidopyrimidine glycosylase -
CH576_RS00240 48986..50005 - 1020 WP_105894715.1 outer membrane-stress sensor serine endopeptidase DegS -
CH576_RS00245 50006..51124 - 1119 WP_105894716.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T109849 WP_005651560.1 NZ_CP031691:45911-46309 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T109849 NZ_CP031691:45911-46309 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCGGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT109849 WP_005648011.1 NZ_CP031691:45678-45911 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT109849 NZ_CP031691:45678-45911 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References