109844

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 568348..568826 Replicon chromosome
Accession NZ_CP031690
Organism Haemophilus influenzae strain P617-9224

Toxin (Protein)


Gene name VapD Uniprot ID Q4QN95
Locus tag CH578_RS02855 Protein ID WP_011272058.1
Coordinates 568548..568826 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q4QN94
Locus tag CH578_RS02850 Protein ID WP_011272059.1
Coordinates 568348..568539 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH578_RS02830 564556..565539 + 984 WP_070828394.1 DNA polymerase III subunit delta' -
CH578_RS02835 565594..566376 + 783 WP_070828393.1 YchF/TatD family DNA exonuclease -
CH578_RS02840 566403..566927 + 525 WP_038440582.1 DUF1523 family protein -
CH578_RS02845 566978..568276 + 1299 WP_005691371.1 hemolysin family protein -
CH578_RS02850 568348..568539 + 192 WP_011272059.1 DUF5397 family protein Antitoxin
CH578_RS02855 568548..568826 + 279 WP_011272058.1 virulence-associated protein VapD Toxin
CH578_RS02860 568919..569449 + 531 WP_038440586.1 hypothetical protein -
CH578_RS02865 569521..571020 + 1500 WP_011272056.1 fused PTS fructose transporter subunit IIA/HPr protein -
CH578_RS02870 571022..571963 + 942 WP_011272055.1 1-phosphofructokinase -
CH578_RS02875 571965..573635 + 1671 WP_011272054.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10647.08 Da        Isoelectric Point: 4.9670

>T109844 WP_011272058.1 NZ_CP031690:568548-568826 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T109844 NZ_CP031690:568548-568826 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTGGCGCAGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAACATGAATGAAGATATGGCGA
ATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGCGCTTTTCGTATT
GAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7073.06 Da        Isoelectric Point: 3.8431

>AT109844 WP_011272059.1 NZ_CP031690:568348-568539 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSYLLEDPEAE

Download         Length: 192 bp

>AT109844 NZ_CP031690:568348-568539 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGCTTAT
CTTACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6ZI0
PDB 6ZN8
PDB 6ZI1

Antitoxin

Source ID Structure
PDB 6ZN8
AlphaFold DB Q4QN94

References