Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 321794..322398 Replicon chromosome
Accession NZ_CP031690
Organism Haemophilus influenzae strain P617-9224

Toxin (Protein)


Gene name relE Uniprot ID A0A2S9RBL9
Locus tag CH578_RS01610 Protein ID WP_050948779.1
Coordinates 321794..322102 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4QMK8
Locus tag CH578_RS01615 Protein ID WP_005692346.1
Coordinates 322102..322398 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH578_RS01600 316903..318201 - 1299 WP_006995277.1 trigger factor -
CH578_RS01605 318502..321737 + 3236 Protein_296 TonB-dependent receptor -
CH578_RS01610 321794..322102 - 309 WP_050948779.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
CH578_RS01615 322102..322398 - 297 WP_005692346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CH578_RS01620 322518..323372 - 855 WP_070828147.1 DUF3298 domain-containing protein -
CH578_RS01625 323391..325250 - 1860 WP_070828148.1 selenocysteine-specific translation elongation factor -
CH578_RS01630 325247..326632 - 1386 WP_070828149.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-99)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11949.72 Da        Isoelectric Point: 7.8657

>T109842 WP_050948779.1 NZ_CP031690:c322102-321794 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IRDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T109842 NZ_CP031690:c322102-321794 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCGATTTGGTACTGATTTACCAATACGTT
ATACGCGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT109842 WP_005692346.1 NZ_CP031690:c322398-322102 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT109842 NZ_CP031690:c322398-322102 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGTTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9RBL9

Antitoxin

Source ID Structure
AlphaFold DB Q4QMK8

References