Detailed information of TA system TA109830

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 373678..374149
• Replicon: chromosome
• Accession: NZ_CP031688
• Organism: Haemophilus influenzae strain P636-8296

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A806DTA9
• Locus tag: CH597_RS01850
• Protein ID: WP_005654546.1
• Coordinates: 373678..373860 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: CH597_RS01855
• Protein ID: WP_061671753.1
• Coordinates: 373853..374149 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH597_RS01845	370404..373409	+	3006	WP_116965481.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
CH597_RS01850	373678..373860	+	183	WP_005654546.1	shikimate 5-dehydrogenase	Toxin
CH597_RS01855	373853..374149	+	297	WP_061671753.1	helix-turn-helix transcriptional regulator	Antitoxin
CH597_RS01860	374333..376249	+	1917	WP_070828340.1	ABC transporter ATP-binding protein	-
CH597_RS01865	376259..376795	+	537	WP_011272152.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
CH597_RS01870	376811..377362	+	552	WP_070828341.1	Sua5/YciO/YrdC/YwlC family protein	-
CH597_RS01875	377366..378172	+	807	WP_011272150.1	shikimate dehydrogenase	-
CH597_RS01880	378184..378936	+	753	WP_011272149.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7318.33 Da
• Isoelectric Point: 6.3057

>T109830 WP_005654546.1 NZ_CP031688:373678-373860 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Nucleotide

• Length: 183 bp

>T109830 NZ_CP031688:373678-373860 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACAGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11106.97 Da
• Isoelectric Point: 10.3139

>AT109830 WP_061671753.1 NZ_CP031688:373853-374149 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRIKNA

Nucleotide

• Length: 297 bp

>AT109830 NZ_CP031688:373853-374149 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGTCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTATTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGATAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A806DTA9