Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 45685..46316 Replicon chromosome
Accession NZ_CP031688
Organism Haemophilus influenzae strain P636-8296

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag CH597_RS00230 Protein ID WP_005651560.1
Coordinates 45918..46316 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag CH597_RS00225 Protein ID WP_005648011.1
Coordinates 45685..45918 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH597_RS00200 41165..42367 - 1203 WP_011272308.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
CH597_RS00205 42530..43195 + 666 WP_013526173.1 DNA repair protein RadC -
CH597_RS00210 43409..43645 + 237 WP_005542826.1 50S ribosomal protein L28 -
CH597_RS00215 43657..43827 + 171 WP_005613503.1 50S ribosomal protein L33 -
CH597_RS00220 44174..45538 + 1365 WP_005651563.1 diaminobutyrate--2-oxoglutarate transaminase -
CH597_RS00225 45685..45918 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
CH597_RS00230 45918..46316 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
CH597_RS00235 46336..47871 + 1536 WP_011272306.1 L-2,4-diaminobutyrate decarboxylase -
CH597_RS00240 48103..48918 + 816 WP_011272305.1 DNA-formamidopyrimidine glycosylase -
CH597_RS00245 48992..50014 - 1023 WP_005693292.1 outer membrane-stress sensor serine endopeptidase DegS -
CH597_RS00250 50015..51133 - 1119 WP_011272304.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T109828 WP_005651560.1 NZ_CP031688:45918-46316 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T109828 NZ_CP031688:45918-46316 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCTGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT109828 WP_005648011.1 NZ_CP031688:45685-45918 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT109828 NZ_CP031688:45685-45918 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References