Detailed information of TA system TA109820

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 752058..752695
• Replicon: chromosome
• Accession: NZ_CP031686
• Organism: Haemophilus influenzae strain P642-4396

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: E4QWH2
• Locus tag: CH603_RS03910
• Protein ID: WP_005649049.1
• Coordinates: 752058..752462 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: E4QWH3
• Locus tag: CH603_RS03915
• Protein ID: WP_005649046.1
• Coordinates: 752459..752695 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH603_RS03880	747616..748182	+	567	WP_005662944.1	elongation factor P	-
CH603_RS03890	748534..749121	-	588	WP_005654063.1	primosomal replication protein	-
CH603_RS03895	749154..750506	-	1353	WP_005688977.1	Na+/H+ antiporter family protein	-
CH603_RS03900	750821..751510	-	690	WP_005688979.1	ribonuclease T	-
CH603_RS03905	751584..751991	-	408	WP_005688980.1	lactoylglutathione lyase	-
CH603_RS03910	752058..752462	-	405	WP_005649049.1	type II toxin-antitoxin system VapC family toxin	Toxin
CH603_RS03915	752459..752695	-	237	WP_005649046.1	antitoxin	Antitoxin
CH603_RS03920	752788..753513	-	726	WP_005688983.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
CH603_RS03925	753566..754084	-	519	WP_005688985.1	isoprenylcysteine carboxyl methyltransferase family protein	-
CH603_RS03930	754304..756070	+	1767	WP_005688987.1	aspartate--tRNA ligase	-
CH603_RS03935	756132..757004	+	873	WP_005688989.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (6-44)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15692.29 Da
• Isoelectric Point: 8.9777

>T109820 WP_005649049.1 NZ_CP031686:c752462-752058 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIIAERVSQLLPNDRLVMSFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Nucleotide

• Length: 405 bp

>T109820 NZ_CP031686:c752462-752058 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTATTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATGAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTGAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGCGACCTATCGGAAATAATGATCTATGGATCGCTTGTCACGCATT
GAGTTTAAATGCCGTTCTTATTACACATAATGTAAAAGAATTTCAGCGAATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9037.19 Da
• Isoelectric Point: 4.2342

>AT109820 WP_005649046.1 NZ_CP031686:c752695-752459 [Haemophilus influenzae]
MLTKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Nucleotide

• Length: 237 bp

>AT109820 NZ_CP031686:c752695-752459 [Haemophilus influenzae]
ATGCTTACTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Structures

Toxin

• AlphaFold DB: E4QWH2

Antitoxin

• AlphaFold DB: E4QWH3