109815

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 559466..559944 Replicon chromosome
Accession NZ_CP031685
Organism Haemophilus influenzae strain P650-8603

Toxin (Protein)


Gene name VapD Uniprot ID A0A0H3PEZ5
Locus tag CH611_RS02830 Protein ID WP_005656500.1
Coordinates 559666..559944 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0K9KX05
Locus tag CH611_RS02825 Protein ID WP_012055040.1
Coordinates 559466..559657 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH611_RS02800 555045..555677 + 633 WP_162877137.1 dTMP kinase -
CH611_RS02805 555674..556657 + 984 WP_116945287.1 DNA polymerase III subunit delta' -
CH611_RS02810 556712..557494 + 783 WP_116945286.1 YchF/TatD family DNA exonuclease -
CH611_RS02815 557521..558045 + 525 WP_005652096.1 DUF1523 family protein -
CH611_RS02820 558096..559394 + 1299 WP_116945285.1 hemolysin family protein -
CH611_RS02825 559466..559657 + 192 WP_012055040.1 DUF5397 family protein Antitoxin
CH611_RS02830 559666..559944 + 279 WP_005656500.1 virulence-associated protein VapD Toxin
CH611_RS02835 560037..560567 + 531 WP_005656499.1 hypothetical protein -
CH611_RS02840 560639..562138 + 1500 WP_116945284.1 fused PTS fructose transporter subunit IIA/HPr protein -
CH611_RS02845 562140..563081 + 942 WP_116945283.1 1-phosphofructokinase -
CH611_RS02850 563083..564753 + 1671 WP_116945282.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.09 Da        Isoelectric Point: 5.7408

>T109815 WP_005656500.1 NZ_CP031685:559666-559944 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T109815 NZ_CP031685:559666-559944 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGTGTTCAACAGGCTTATACAGA
CATTGGCGCAGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAATATGAATGAAGATATGGCGA
ATCTTTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGTGCTTTTCGTATT
GAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7018.97 Da        Isoelectric Point: 3.9930

>AT109815 WP_012055040.1 NZ_CP031685:559466-559657 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDALVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT109815 NZ_CP031685:559466-559657 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGCGATGCGTTGGTGAATATCACATTATTACAATCTGGAGAAAAAGACATTTATCGCTTAT
CTCACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3PEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9KX05

References