Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 370207..370855 Replicon chromosome
Accession NZ_CP031685
Organism Haemophilus influenzae strain P650-8603

Toxin (Protein)


Gene name toxT Uniprot ID -
Locus tag CH611_RS01850 Protein ID WP_116945636.1
Coordinates 370207..370566 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag CH611_RS01855 Protein ID WP_005650837.1
Coordinates 370559..370855 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH611_RS01845 366992..369937 + 2946 WP_116953892.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
CH611_RS01850 370207..370566 + 360 WP_116945636.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CH611_RS01855 370559..370855 + 297 WP_005650837.1 helix-turn-helix transcriptional regulator Antitoxin
CH611_RS01860 371039..372955 + 1917 WP_116945637.1 ABC transporter ATP-binding protein -
CH611_RS01865 372965..373501 + 537 WP_116945638.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
CH611_RS01870 373517..374068 + 552 WP_116945639.1 Sua5/YciO/YrdC/YwlC family protein -
CH611_RS01875 374072..374890 + 819 WP_116945640.1 shikimate dehydrogenase -
CH611_RS01880 374887..375444 + 558 WP_116945641.1 DNA-3-methyladenine glycosylase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(36-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 14309.70 Da        Isoelectric Point: 10.1179

>T109814 WP_116945636.1 NZ_CP031685:370207-370566 [Haemophilus influenzae]
MYEILFYKDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKLYVKHLDGEIWELRPIRDRILFARLM
DGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Download         Length: 360 bp

>T109814 NZ_CP031685:370207-370566 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAAAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAAAGTTATTAAGCGAACTCGGGACGTCTGTTGGCA
AACTCTATGTTAAACATTTAGACGGTGAAATTTGGGAACTTCGCCCAATTCGGGATCGCATCTTGTTTGCAAGATTAATG
GACGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAACGAGAAATCCAAACAGCCCAACA
ACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT109814 WP_005650837.1 NZ_CP031685:370559-370855 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp

>AT109814 NZ_CP031685:370559-370855 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTATTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTATCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References