Detailed information of TA system TA109812

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 305276..305880
• Replicon: chromosome
• Accession: NZ_CP031685
• Organism: Haemophilus influenzae strain P650-8603

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CH611_RS01550
• Protein ID: WP_105894851.1
• Coordinates: 305276..305584 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q4QMK8
• Locus tag: CH611_RS01555
• Protein ID: WP_005692346.1
• Coordinates: 305584..305880 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH611_RS01540	300370..301668	-	1299	WP_116945656.1	trigger factor	-
CH611_RS01545	301998..305219	+	3222	WP_116953891.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
CH611_RS01550	305276..305584	-	309	WP_105894851.1	type II toxin-antitoxin system YafQ family toxin	Toxin
CH611_RS01555	305584..305880	-	297	WP_005692346.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CH611_RS01560	306000..306854	-	855	WP_116945588.1	DUF3298 domain-containing protein	-
CH611_RS01565	306873..308732	-	1860	WP_116945587.1	selenocysteine-specific translation elongation factor	-
CH611_RS01570	308729..310114	-	1386	WP_116939688.1	L-seryl-tRNA(Sec) selenium transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (8-98)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-93)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11892.63 Da
• Isoelectric Point: 7.2391

>T109812 WP_105894851.1 NZ_CP031685:c305584-305276 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYQDCHIQGNLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Nucleotide

• Length: 309 bp

>T109812 NZ_CP031685:c305584-305276 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCAAGATTGCCATATTCAAGGCAATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11003.27 Da
• Isoelectric Point: 4.2845

>AT109812 WP_005692346.1 NZ_CP031685:c305880-305584 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Nucleotide

• Length: 297 bp

>AT109812 NZ_CP031685:c305880-305584 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Structures

Antitoxin

• AlphaFold DB: Q4QMK8