Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 689262..689899 Replicon chromosome
Accession NZ_CP031684
Organism Haemophilus influenzae strain P652-8881

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A0Y7JDC3
Locus tag CH613_RS03545 Protein ID WP_005659980.1
Coordinates 689262..689666 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag CH613_RS03550 Protein ID WP_005656316.1
Coordinates 689663..689899 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH613_RS03515 684823..685389 + 567 WP_005544066.1 elongation factor P -
CH613_RS03525 685741..686325 - 585 WP_005686764.1 primosomal replication protein -
CH613_RS03530 686357..687709 - 1353 WP_005686762.1 Na+/H+ antiporter family protein -
CH613_RS03535 688025..688714 - 690 WP_005686760.1 ribonuclease T -
CH613_RS03540 688788..689195 - 408 WP_005654069.1 lactoylglutathione lyase -
CH613_RS03545 689262..689666 - 405 WP_005659980.1 type II toxin-antitoxin system VapC family toxin Toxin
CH613_RS03550 689663..689899 - 237 WP_005656316.1 antitoxin Antitoxin
CH613_RS03555 689992..690717 - 726 WP_005669008.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
CH613_RS03560 690770..691288 - 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
CH613_RS03565 691507..693273 + 1767 WP_011961734.1 aspartate--tRNA ligase -
CH613_RS03570 693335..694207 + 873 WP_048954586.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15660.23 Da        Isoelectric Point: 8.9777

>T109807 WP_005659980.1 NZ_CP031684:c689666-689262 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T109807 NZ_CP031684:c689666-689262 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT109807 WP_005656316.1 NZ_CP031684:c689899-689663 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT109807 NZ_CP031684:c689899-689663 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JDC3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References