Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 562794..563131 Replicon chromosome
Accession NZ_CP031684
Organism Haemophilus influenzae strain P652-8881

Toxin (Protein)


Gene name VapD Uniprot ID A0A2R3FLH7
Locus tag CH613_RS02890 Protein ID WP_005686917.1
Coordinates 562994..563131 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag CH613_RS02885 Protein ID WP_005649350.1
Coordinates 562794..562985 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH613_RS02860 558373..559005 + 633 WP_005686927.1 dTMP kinase -
CH613_RS02865 559002..559985 + 984 WP_005686925.1 DNA polymerase III subunit delta' -
CH613_RS02870 560040..560822 + 783 WP_005686923.1 YchF/TatD family DNA exonuclease -
CH613_RS02875 560849..561373 + 525 WP_005686921.1 DUF1523 family protein -
CH613_RS02880 561424..562722 + 1299 WP_032821624.1 hemolysin family protein -
CH613_RS02885 562794..562985 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
CH613_RS02890 562994..563131 + 138 WP_005686917.1 hypothetical protein Toxin
CH613_RS02895 563224..563754 + 531 WP_005686915.1 hypothetical protein -
CH613_RS02900 563826..565325 + 1500 WP_005686912.1 fused PTS fructose transporter subunit IIA/HPr protein -
CH613_RS02905 565327..566268 + 942 WP_005686910.1 1-phosphofructokinase -
CH613_RS02910 566270..567940 + 1671 WP_005686908.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5415.04 Da        Isoelectric Point: 4.4640

>T109806 WP_005686917.1 NZ_CP031684:562994-563131 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIRAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T109806 NZ_CP031684:562994-563131 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTCGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT109806 WP_005649350.1 NZ_CP031684:562794-562985 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT109806 NZ_CP031684:562794-562985 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTAT
CTCACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3FLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References