Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-DnaT |
Location | 75220..75754 | Replicon | chromosome |
Accession | NZ_CP031684 | ||
Organism | Haemophilus influenzae strain P652-8881 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A2R3GCN3 |
Locus tag | CH613_RS00390 | Protein ID | WP_005651512.1 |
Coordinates | 75464..75754 (+) | Length | 97 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | E7A5Y2 |
Locus tag | CH613_RS00385 | Protein ID | WP_005651514.1 |
Coordinates | 75220..75474 (+) | Length | 85 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CH613_RS00345 | 70400..70660 | + | 261 | WP_005663579.1 | hypothetical protein | - |
CH613_RS00350 | 70690..71055 | + | 366 | WP_005686191.1 | endonuclease domain-containing protein | - |
CH613_RS00355 | 71393..73459 | + | 2067 | WP_005686190.1 | glycine--tRNA ligase subunit beta | - |
CH613_RS00365 | 73821..74360 | + | 540 | WP_005659144.1 | hypothetical protein | - |
CH613_RS00370 | 74390..74698 | + | 309 | WP_005659142.1 | P2 family phage major capsid protein | - |
CH613_RS00375 | 74698..74922 | + | 225 | WP_005659141.1 | hypothetical protein | - |
CH613_RS00385 | 75220..75474 | + | 255 | WP_005651514.1 | stability protein StbD | Antitoxin |
CH613_RS00390 | 75464..75754 | + | 291 | WP_005651512.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
CH613_RS00395 | 75835..76044 | + | 210 | WP_074030365.1 | hypothetical protein | - |
CH613_RS08915 | 76214..76351 | + | 138 | WP_005659136.1 | hypothetical protein | - |
CH613_RS00400 | 76883..77917 | - | 1035 | WP_005659128.1 | DNA polymerase III subunit delta | - |
CH613_RS00405 | 77917..78420 | - | 504 | WP_005659127.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11482.41 Da Isoelectric Point: 10.6484
>T109802 WP_005651512.1 NZ_CP031684:75464-75754 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH
Download Length: 291 bp
>T109802 NZ_CP031684:75464-75754 [Haemophilus influenzae]
ATGACTTATAAACTCATTTTTGATAAACGCGCATTAAAAGAATGGAATAAATTGGGGGAAACCTTACGCCAACAATTTAA
AAATAAATTAGCCGAAAGAATGATAAATCCACGCATTCAAGCCGACAAATTAAAGGGCGAAAATGATTTATATAAAATCA
AATTAAGAAGCGCTGGTTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACTATTATTGTTGTATCTGTTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA
ATGACTTATAAACTCATTTTTGATAAACGCGCATTAAAAGAATGGAATAAATTGGGGGAAACCTTACGCCAACAATTTAA
AAATAAATTAGCCGAAAGAATGATAAATCCACGCATTCAAGCCGACAAATTAAAGGGCGAAAATGATTTATATAAAATCA
AATTAAGAAGCGCTGGTTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACTATTATTGTTGTATCTGTTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9419.78 Da Isoelectric Point: 4.0737
>AT109802 WP_005651514.1 NZ_CP031684:75220-75474 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRMANERLATLEPVEVD
LNDL
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRMANERLATLEPVEVD
LNDL
Download Length: 255 bp
>AT109802 NZ_CP031684:75220-75474 [Haemophilus influenzae]
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACCCCCGAATTATTCTCTCATA
TGCAAGAATTAATCGAAGATTTAGAGCTCGGCAGAATGGCAAATGAACGGCTAGCCACCCTAGAACCAGTAGAGGTTGAT
CTAAATGACTTATAA
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACCCCCGAATTATTCTCTCATA
TGCAAGAATTAATCGAAGATTTAGAGCTCGGCAGAATGGCAAATGAACGGCTAGCCACCCTAGAACCAGTAGAGGTTGAT
CTAAATGACTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2R3GCN3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5C2QYX4 |