Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 75220..75754 Replicon chromosome
Accession NZ_CP031684
Organism Haemophilus influenzae strain P652-8881

Toxin (Protein)


Gene name relE Uniprot ID A0A2R3GCN3
Locus tag CH613_RS00390 Protein ID WP_005651512.1
Coordinates 75464..75754 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E7A5Y2
Locus tag CH613_RS00385 Protein ID WP_005651514.1
Coordinates 75220..75474 (+) Length 85 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH613_RS00345 70400..70660 + 261 WP_005663579.1 hypothetical protein -
CH613_RS00350 70690..71055 + 366 WP_005686191.1 endonuclease domain-containing protein -
CH613_RS00355 71393..73459 + 2067 WP_005686190.1 glycine--tRNA ligase subunit beta -
CH613_RS00365 73821..74360 + 540 WP_005659144.1 hypothetical protein -
CH613_RS00370 74390..74698 + 309 WP_005659142.1 P2 family phage major capsid protein -
CH613_RS00375 74698..74922 + 225 WP_005659141.1 hypothetical protein -
CH613_RS00385 75220..75474 + 255 WP_005651514.1 stability protein StbD Antitoxin
CH613_RS00390 75464..75754 + 291 WP_005651512.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CH613_RS00395 75835..76044 + 210 WP_074030365.1 hypothetical protein -
CH613_RS08915 76214..76351 + 138 WP_005659136.1 hypothetical protein -
CH613_RS00400 76883..77917 - 1035 WP_005659128.1 DNA polymerase III subunit delta -
CH613_RS00405 77917..78420 - 504 WP_005659127.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-83)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 97 a.a.        Molecular weight: 11482.41 Da        Isoelectric Point: 10.6484

>T109802 WP_005651512.1 NZ_CP031684:75464-75754 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

>T109802 NZ_CP031684:75464-75754 [Haemophilus influenzae]
ATGACTTATAAACTCATTTTTGATAAACGCGCATTAAAAGAATGGAATAAATTGGGGGAAACCTTACGCCAACAATTTAA
AAATAAATTAGCCGAAAGAATGATAAATCCACGCATTCAAGCCGACAAATTAAAGGGCGAAAATGATTTATATAAAATCA
AATTAAGAAGCGCTGGTTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACTATTATTGTTGTATCTGTTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9419.78 Da        Isoelectric Point: 4.0737

>AT109802 WP_005651514.1 NZ_CP031684:75220-75474 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRMANERLATLEPVEVD
LNDL

Download         Length: 255 bp

>AT109802 NZ_CP031684:75220-75474 [Haemophilus influenzae]
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACCCCCGAATTATTCTCTCATA
TGCAAGAATTAATCGAAGATTTAGAGCTCGGCAGAATGGCAAATGAACGGCTAGCCACCCTAGAACCAGTAGAGGTTGAT
CTAAATGACTTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2R3GCN3


Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QYX4

References