Detailed information of TA system TA109798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 753187..753824
• Replicon: chromosome
• Accession: NZ_CP031683
• Organism: Haemophilus influenzae strain P662-7189

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: E4QWH2
• Locus tag: CH621_RS03895
• Protein ID: WP_005649049.1
• Coordinates: 753187..753591 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: E4QWH3
• Locus tag: CH621_RS03900
• Protein ID: WP_005649046.1
• Coordinates: 753588..753824 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH621_RS03865	748744..749310	+	567	WP_005544066.1	elongation factor P	-
CH621_RS03875	749661..750248	-	588	WP_005654063.1	primosomal replication protein	-
CH621_RS03880	750281..751633	-	1353	WP_105872272.1	Na+/H+ antiporter family protein	-
CH621_RS03885	751950..752639	-	690	WP_021035684.1	ribonuclease T	-
CH621_RS03890	752713..753120	-	408	WP_048949995.1	lactoylglutathione lyase	-
CH621_RS03895	753187..753591	-	405	WP_005649049.1	type II toxin-antitoxin system VapC family toxin	Toxin
CH621_RS03900	753588..753824	-	237	WP_005649046.1	antitoxin	Antitoxin
CH621_RS03905	753917..754642	-	726	WP_011271987.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
CH621_RS03910	754695..755213	-	519	WP_005649040.1	isoprenylcysteine carboxyl methyltransferase family protein	-
CH621_RS03915	755433..757199	+	1767	WP_050838110.1	aspartate--tRNA ligase	-
CH621_RS03920	757221..757694	+	474	WP_011271985.1	dihydroneopterin triphosphate diphosphatase	-
CH621_RS03925	757706..758446	+	741	WP_005649034.1	YebC/PmpR family DNA-binding transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (6-44)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15692.29 Da
• Isoelectric Point: 8.9777

>T109798 WP_005649049.1 NZ_CP031683:c753591-753187 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIIAERVSQLLPNDRLVMSFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Nucleotide

• Length: 405 bp

>T109798 NZ_CP031683:c753591-753187 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTATTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATGAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTGAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGCGACCTATCGGAAATAATGATCTATGGATCGCTTGTCACGCATT
GAGTTTAAATGCCGTTCTTATTACACATAATGTAAAAGAATTTCAGCGAATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9037.19 Da
• Isoelectric Point: 4.2342

>AT109798 WP_005649046.1 NZ_CP031683:c753824-753588 [Haemophilus influenzae]
MLTKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Nucleotide

• Length: 237 bp

>AT109798 NZ_CP031683:c753824-753588 [Haemophilus influenzae]
ATGCTTACTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Structures

Toxin

• AlphaFold DB: E4QWH2

Antitoxin

• AlphaFold DB: E4QWH3