Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 583603..584081 Replicon chromosome
Accession NZ_CP031683
Organism Haemophilus influenzae strain P662-7189

Toxin (Protein)


Gene name VapD Uniprot ID Q4QN95
Locus tag CH621_RS02935 Protein ID WP_011272058.1
Coordinates 583803..584081 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q4QN94
Locus tag CH621_RS02930 Protein ID WP_011272059.1
Coordinates 583603..583794 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH621_RS02910 579811..580794 + 984 WP_116961635.1 DNA polymerase III subunit delta' -
CH621_RS02915 580849..581631 + 783 WP_105872255.1 YchF/TatD family DNA exonuclease -
CH621_RS02920 581658..582182 + 525 WP_005656502.1 DUF1523 family protein -
CH621_RS02925 582233..583531 + 1299 WP_032821894.1 hemolysin family protein -
CH621_RS02930 583603..583794 + 192 WP_011272059.1 DUF5397 family protein Antitoxin
CH621_RS02935 583803..584081 + 279 WP_011272058.1 virulence-associated protein VapD Toxin
CH621_RS02940 584174..584704 + 531 WP_005649345.1 hypothetical protein -
CH621_RS02945 584776..586275 + 1500 WP_011272056.1 fused PTS fructose transporter subunit IIA/HPr protein -
CH621_RS02950 586277..587218 + 942 WP_011272055.1 1-phosphofructokinase -
CH621_RS02955 587220..588890 + 1671 WP_105872256.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10647.08 Da        Isoelectric Point: 4.9670

>T109796 WP_011272058.1 NZ_CP031683:583803-584081 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T109796 NZ_CP031683:583803-584081 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTGGCGCAGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAACATGAATGAAGATATGGCGA
ATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGCGCTTTTCGTATT
GAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7073.06 Da        Isoelectric Point: 3.8431

>AT109796 WP_011272059.1 NZ_CP031683:583603-583794 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSYLLEDPEAE

Download         Length: 192 bp

>AT109796 NZ_CP031683:583603-583794 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTAT
CTTACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6ZI0
PDB 6ZN8
PDB 6ZI1

Antitoxin

Source ID Structure
PDB 6ZN8
AlphaFold DB Q4QN94

References