Detailed information of TA system TA109795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 46281..46912
• Replicon: chromosome
• Accession: NZ_CP031683
• Organism: Haemophilus influenzae strain P662-7189

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CH621_RS00235
• Protein ID: WP_116961629.1
• Coordinates: 46514..46912 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q4QLV9
• Locus tag: CH621_RS00230
• Protein ID: WP_005648011.1
• Coordinates: 46281..46514 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH621_RS00205	41761..42963	-	1203	WP_011272308.1	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC	-
CH621_RS00210	43126..43791	+	666	WP_013526173.1	DNA repair protein RadC	-
CH621_RS00215	44005..44241	+	237	WP_005542826.1	50S ribosomal protein L28	-
CH621_RS00220	44253..44423	+	171	WP_005613503.1	50S ribosomal protein L33	-
CH621_RS00225	44770..46134	+	1365	WP_005651563.1	diaminobutyrate--2-oxoglutarate transaminase	-
CH621_RS00230	46281..46514	+	234	WP_005648011.1	type II toxin-antitoxin system antitoxin VapB2	Antitoxin
CH621_RS00235	46514..46912	+	399	WP_116961629.1	tRNA(fMet)-specific endonuclease VapC	Toxin
CH621_RS00240	46932..48467	+	1536	WP_048941155.1	L-2,4-diaminobutyrate decarboxylase	-
CH621_RS00245	48699..49514	+	816	WP_105872437.1	DNA-formamidopyrimidine glycosylase	-
CH621_RS00250	49588..50610	-	1023	WP_005693292.1	outer membrane-stress sensor serine endopeptidase DegS	-
CH621_RS00255	50611..51729	-	1119	WP_011272304.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• SpoVT-AbrB domain (7-56)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15081.44 Da
• Isoelectric Point: 8.0514

>T109795 WP_116961629.1 NZ_CP031683:46514-46912 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRLNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Nucleotide

• Length: 399 bp

>T109795 NZ_CP031683:46514-46912 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCCTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCTGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8880.98 Da
• Isoelectric Point: 4.4013

>AT109795 WP_005648011.1 NZ_CP031683:46281-46514 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Nucleotide

• Length: 234 bp

>AT109795 NZ_CP031683:46281-46514 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Structures

Antitoxin

• AlphaFold DB: A0A806DGS0