Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1650985..1651574 Replicon chromosome
Accession NZ_CP031682
Organism Haemophilus influenzae strain P665-7858

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag CH624_RS08480 Protein ID WP_005653200.1
Coordinates 1651326..1651574 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q9R3J9
Locus tag CH624_RS08475 Protein ID WP_005668366.1
Coordinates 1650985..1651329 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH624_RS08460 1646623..1649136 - 2514 WP_042610861.1 fimbrial biogenesis outer membrane usher protein -
CH624_RS08465 1649231..1649929 - 699 WP_032826232.1 fimbria/pilus periplasmic chaperone -
CH624_RS08470 1650250..1650888 + 639 WP_005668364.1 type 1 fimbrial protein -
CH624_RS08475 1650985..1651329 - 345 WP_005668366.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CH624_RS08480 1651326..1651574 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
CH624_RS08485 1651745..1652239 + 495 WP_042610860.1 5-(carboxyamino)imidazole ribonucleotide mutase -
CH624_RS08490 1652309..1653397 + 1089 WP_112109647.1 5-(carboxyamino)imidazole ribonucleotide synthase -
CH624_RS08495 1653537..1654727 + 1191 WP_005657030.1 aspartate/tyrosine/aromatic aminotransferase -
CH624_RS08500 1654833..1655459 - 627 WP_112109648.1 energy-coupling factor ABC transporter ATP-binding protein -
CH624_RS08505 1655461..1656093 - 633 WP_112109649.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T109794 WP_005653200.1 NZ_CP031682:c1651574-1651326 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T109794 NZ_CP031682:c1651574-1651326 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCCCACCCTGAAAATTATATTAAAGGCGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.08 Da        Isoelectric Point: 5.0113

>AT109794 WP_005668366.1 NZ_CP031682:c1651329-1650985 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIKEKIFREKPSLR

Download         Length: 345 bp

>AT109794 NZ_CP031682:c1651329-1650985 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATAATAGCTGGCGATCGTTCACTTAATGCTTTTGTGACGGAAGCGATTAAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A806E3Y3

References