Detailed information of TA system TA109792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1023630..1024212
• Replicon: chromosome
• Accession: NZ_CP031682
• Organism: Haemophilus influenzae strain P665-7858

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CH624_RS05305
• Protein ID: WP_015979439.1
• Coordinates: 1023630..1023782 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A806ED58
• Locus tag: CH624_RS05310
• Protein ID: WP_005642973.1
• Coordinates: 1023811..1024212 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH624_RS05265	1018648..1019151	+	504	WP_075985610.1	hypothetical protein	-
CH624_RS05270	1019170..1019538	+	369	WP_005642993.1	hypothetical protein	-
CH624_RS05275	1019538..1019723	+	186	WP_005667755.1	hypothetical protein	-
CH624_RS05280	1019735..1020016	+	282	WP_075985609.1	hypothetical protein	-
CH624_RS05285	1020067..1020327	+	261	WP_005667751.1	hypothetical protein	-
CH624_RS05290	1020330..1022657	+	2328	WP_075985608.1	replication endonuclease	-
CH624_RS05295	1022669..1022980	+	312	WP_005667746.1	hypothetical protein	-
CH624_RS05300	1022990..1023508	+	519	WP_075985607.1	phage N-6-adenine-methyltransferase	-
CH624_RS05305	1023630..1023782	+	153	WP_015979439.1	type II toxin-antitoxin system HicA family toxin	Toxin
CH624_RS05310	1023811..1024212	+	402	WP_005642973.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CH624_RS05315	1024240..1024500	-	261	WP_075985638.1	ogr/Delta-like zinc finger family protein	-
CH624_RS05320	1024581..1025618	-	1038	WP_075985606.1	phage portal protein	-
CH624_RS05325	1025608..1027431	-	1824	WP_015967402.1	terminase ATPase subunit family protein	-
CH624_RS05330	1027635..1028528	+	894	WP_116938017.1	GPO family capsid scaffolding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1015120..1046306	31186

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (2-50)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5789.66 Da
• Isoelectric Point: 10.2641

>T109792 WP_015979439.1 NZ_CP031682:1023630-1023782 [Haemophilus influenzae]
MIEEDGWYLDRVKGSHHQYKHPTKKGTVTIPHPRKDLGHLEKSIKKQAGL

Nucleotide

• Length: 153 bp

>T109792 NZ_CP031682:1023630-1023782 [Haemophilus influenzae]
ATGATAGAAGAGGACGGTTGGTATTTAGATAGAGTTAAAGGTAGTCATCATCAATACAAACATCCTACAAAAAAGGGAAC
GGTCACGATTCCCCACCCAAGGAAAGACTTGGGGCATTTAGAAAAAAGCATTAAAAAACAAGCGGGGCTGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14922.06 Da
• Isoelectric Point: 4.3937

>AT109792 WP_005642973.1 NZ_CP031682:1023811-1024212 [Haemophilus influenzae]
MLYPICIEKVNDGYVVSVPDVPGCFSAGDTLSEAMLNAKEAISFHIEGMLEDDEELPKSNPIEQYINQPEYKDFIVTVVD
VDLTHLMGKAEKINITVPALLLHRIDQFIATHPEYKNRSNFLSQLATNRLLSA

Nucleotide

• Length: 402 bp

>AT109792 NZ_CP031682:1023811-1024212 [Haemophilus influenzae]
ATGTTATACCCAATTTGTATCGAAAAAGTAAATGATGGTTATGTGGTATCTGTGCCAGATGTGCCAGGCTGTTTTTCTGC
TGGGGATACCTTATCAGAAGCAATGTTAAACGCAAAAGAAGCAATCTCTTTTCACATTGAAGGGATGTTAGAAGATGATG
AAGAATTGCCTAAATCTAACCCAATAGAACAATATATTAATCAGCCCGAATATAAAGATTTTATTGTCACTGTTGTTGAT
GTAGATTTAACTCATTTAATGGGTAAGGCAGAAAAAATTAATATTACGGTTCCTGCGTTATTACTGCACCGCATTGATCA
GTTTATTGCCACCCATCCAGAATATAAAAATAGAAGTAACTTTTTGTCTCAACTAGCAACAAATAGATTACTTTCTGCAT
AA

Structures

Antitoxin

• AlphaFold DB: A0A806ED58