109791

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 577827..578164 Replicon chromosome
Accession NZ_CP031682
Organism Haemophilus influenzae strain P665-7858

Toxin (Protein)


Gene name VapD Uniprot ID -
Locus tag CH624_RS02930 Protein ID WP_032823994.1
Coordinates 578027..578164 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag CH624_RS02925 Protein ID WP_005649350.1
Coordinates 577827..578018 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH624_RS02900 573406..574038 + 633 WP_032828392.1 dTMP kinase -
CH624_RS02905 574035..575018 + 984 WP_010868989.1 DNA polymerase III subunit delta' -
CH624_RS02910 575073..575855 + 783 WP_005693710.1 YchF/TatD family DNA exonuclease -
CH624_RS02915 575882..576406 + 525 WP_005652096.1 DUF1523 family protein -
CH624_RS02920 576457..577755 + 1299 WP_112103062.1 hemolysin family protein -
CH624_RS02925 577827..578018 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
CH624_RS02930 578027..578164 + 138 WP_032823994.1 virulence-associated protein D Toxin
CH624_RS02935 578257..578787 + 531 WP_032823993.1 hypothetical protein -
CH624_RS02940 578859..580358 + 1500 WP_116937986.1 fused PTS fructose transporter subunit IIA/HPr protein -
CH624_RS02945 580360..581301 + 942 WP_112109802.1 1-phosphofructokinase -
CH624_RS02950 581303..582973 + 1671 WP_112109801.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5326.97 Da        Isoelectric Point: 4.3714

>T109791 WP_032823994.1 NZ_CP031682:578027-578164 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYIDIGAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T109791 NZ_CP031682:578027-578164 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAACAGGCTTATATAGA
CATTGGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT109791 WP_005649350.1 NZ_CP031682:577827-578018 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT109791 NZ_CP031682:577827-578018 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGATTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References