Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 384922..385393 Replicon chromosome
Accession NZ_CP031682
Organism Haemophilus influenzae strain P665-7858

Toxin (Protein)


Gene name toxT Uniprot ID -
Locus tag CH624_RS01920 Protein ID WP_042611291.1
Coordinates 384922..385104 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag CH624_RS01925 Protein ID WP_042611290.1
Coordinates 385097..385393 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH624_RS01905 380753..380992 - 240 WP_005651317.1 hypothetical protein -
CH624_RS01915 381683..384652 + 2970 WP_162877837.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
CH624_RS01920 384922..385104 + 183 WP_042611291.1 shikimate dehydrogenase Toxin
CH624_RS01925 385097..385393 + 297 WP_042611290.1 helix-turn-helix transcriptional regulator Antitoxin
CH624_RS01930 385577..387493 + 1917 WP_112109999.1 ABC transporter ATP-binding protein -
CH624_RS01935 387503..388039 + 537 WP_112109998.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
CH624_RS01940 388055..388606 + 552 WP_038439523.1 Sua5/YciO/YrdC/YwlC family protein -
CH624_RS01945 388610..389416 + 807 WP_112109997.1 shikimate dehydrogenase -
CH624_RS01950 389630..390193 + 564 WP_112109996.1 DNA-3-methyladenine glycosylase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7306.28 Da        Isoelectric Point: 6.3057

>T109790 WP_042611291.1 NZ_CP031682:384922-385104 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVTQTAQQRLSELKERLKNE

Download         Length: 183 bp

>T109790 NZ_CP031682:384922-385104 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTAAAAGAGTATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAACCCAAACTGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.00 Da        Isoelectric Point: 10.6883

>AT109790 WP_042611290.1 NZ_CP031682:385097-385393 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRKSNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp

>AT109790 NZ_CP031682:385097-385393 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCAAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGTCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References