Detailed information of TA system TA109789

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 328229..328833
• Replicon: chromosome
• Accession: NZ_CP031682
• Organism: Haemophilus influenzae strain P665-7858

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q9S658
• Locus tag: CH624_RS01665
• Protein ID: WP_042593918.1
• Coordinates: 328229..328537 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q4QMK8
• Locus tag: CH624_RS01670
• Protein ID: WP_005692346.1
• Coordinates: 328537..328833 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH624_RS01655	323367..324668	-	1302	WP_112110011.1	trigger factor	-
CH624_RS01660	324970..328170	+	3201	WP_116961656.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
CH624_RS01665	328229..328537	-	309	WP_042593918.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
CH624_RS01670	328537..328833	-	297	WP_005692346.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CH624_RS01675	328953..329807	-	855	WP_112110009.1	DUF3298 domain-containing protein	-
CH624_RS01680	329826..331685	-	1860	WP_112110008.1	selenocysteine-specific translation elongation factor	-
CH624_RS01685	331682..333067	-	1386	WP_112110007.1	L-seryl-tRNA(Sec) selenium transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-99)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-93)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11921.67 Da
• Isoelectric Point: 7.2393

>T109789 WP_042593918.1 NZ_CP031682:c328537-328229 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Nucleotide

• Length: 309 bp

>T109789 NZ_CP031682:c328537-328229 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCGATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11003.27 Da
• Isoelectric Point: 4.2845

>AT109789 WP_005692346.1 NZ_CP031682:c328833-328537 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Nucleotide

• Length: 297 bp

>AT109789 NZ_CP031682:c328833-328537 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGTTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Structures

Toxin

• AlphaFold DB: Q9S658

Antitoxin

• AlphaFold DB: Q4QMK8