Detailed information of TA system TA109785

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 888920..889454
• Replicon: chromosome
• Accession: NZ_CP031681
• Organism: Haemophilus influenzae strain P669-6977

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0M1GMI0
• Locus tag: CH628_RS04765
• Protein ID: WP_012054909.1
• Coordinates: 889164..889454 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0M1GP19
• Locus tag: CH628_RS04760
• Protein ID: WP_032823666.1
• Coordinates: 888920..889174 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH628_RS04720	884116..884343	+	228	WP_048950149.1	hypothetical protein	-
CH628_RS04725	884386..884601	+	216	WP_032823658.1	AlpA family phage regulatory protein	-
CH628_RS04730	884582..884812	+	231	WP_012054915.1	hypothetical protein	-
CH628_RS04735	884872..885465	+	594	WP_105886805.1	host cell division inhibitor Icd-like protein	-
CH628_RS04740	885458..885697	+	240	WP_105886806.1	hypothetical protein	-
CH628_RS04745	885694..885918	+	225	WP_105886807.1	hypothetical protein	-
CH628_RS04750	885927..886205	+	279	WP_105886808.1	hypothetical protein	-
CH628_RS04755	886215..888422	+	2208	WP_105886809.1	DUF927 domain-containing protein	-
CH628_RS04760	888920..889174	+	255	WP_032823666.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CH628_RS04765	889164..889454	+	291	WP_012054909.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CH628_RS04775	890055..890378	-	324	WP_005653397.1	ribosome-associated translation inhibitor RaiA	-
CH628_RS04780	890568..891197	-	630	WP_038439193.1	outer membrane protein assembly factor BamC	-
CH628_RS04785	891308..892204	-	897	WP_050846026.1	4-hydroxy-tetrahydrodipicolinate synthase	-
CH628_RS04790	892305..892772	+	468	WP_005668209.1	thioredoxin-dependent thiol peroxidase	-
CH628_RS04795	892941..893393	+	453	WP_005648856.1	TonB-system energizer ExbB	-
CH628_RS04800	893397..893840	+	444	WP_005648853.1	TonB system transport protein ExbD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11237.15 Da
• Isoelectric Point: 10.4256

>T109785 WP_012054909.1 NZ_CP031681:889164-889454 [Haemophilus influenzae]
MTYKLTFSPKAKKEWDKLGDTIKNQFKKKLLERLENPHVPADRLSGFSGVFYKIKLRSVGYRLVYEVIEDKVIVYVLAVG
KRERAEVYTAARDRLN

Nucleotide

• Length: 291 bp

>T109785 NZ_CP031681:889164-889454 [Haemophilus influenzae]
ATGACTTATAAACTGACATTTAGCCCAAAGGCAAAGAAAGAATGGGATAAACTTGGCGATACCATAAAAAACCAATTTAA
GAAAAAGTTATTAGAACGCTTAGAAAATCCACACGTGCCAGCAGATCGGCTTTCTGGCTTTTCTGGAGTGTTTTATAAAA
TAAAACTTCGCTCGGTAGGTTATCGTTTAGTTTATGAAGTTATTGAAGATAAAGTTATCGTTTATGTTCTTGCCGTTGGC
AAGCGTGAACGCGCTGAAGTTTACACCGCTGCACGCGATAGATTAAATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9526.91 Da
• Isoelectric Point: 4.1317

>AT109785 WP_032823666.1 NZ_CP031681:888920-889174 [Haemophilus influenzae]
MAIHQILTEQAASITDLKRNPMGVMRESENGVIAILNRNQPAFYCLTPEMFAYMQELIEDAELVRIAEERKAEGGFIEVD
INDL

Nucleotide

• Length: 255 bp

>AT109785 NZ_CP031681:888920-889174 [Haemophilus influenzae]
ATGGCAATTCATCAAATACTAACAGAGCAGGCTGCAAGCATTACCGATCTAAAACGAAACCCTATGGGCGTAATGCGAGA
AAGTGAAAATGGCGTGATTGCTATATTAAATCGTAACCAACCAGCCTTTTATTGTCTTACGCCTGAAATGTTCGCTTATA
TGCAAGAATTAATCGAAGATGCAGAACTAGTACGCATTGCAGAAGAGCGAAAAGCTGAGGGCGGTTTTATTGAGGTTGAT
ATTAATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A0M1GMI0

Antitoxin

• AlphaFold DB: A0A0M1GP19