Detailed information of TA system TA109784

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 815156..815793
• Replicon: chromosome
• Accession: NZ_CP031681
• Organism: Haemophilus influenzae strain P669-6977

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: E4QWH2
• Locus tag: CH628_RS04345
• Protein ID: WP_005649049.1
• Coordinates: 815156..815560 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: E4QWH3
• Locus tag: CH628_RS04350
• Protein ID: WP_005649046.1
• Coordinates: 815557..815793 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH628_RS04315	810716..811282	+	567	WP_005544066.1	elongation factor P	-
CH628_RS04325	811633..812220	-	588	WP_005654063.1	primosomal replication protein	-
CH628_RS04330	812253..813605	-	1353	WP_005694344.1	Na+/H+ antiporter family protein	-
CH628_RS04335	813919..814608	-	690	WP_011271988.1	ribonuclease T	-
CH628_RS04340	814682..815089	-	408	WP_005688980.1	lactoylglutathione lyase	-
CH628_RS04345	815156..815560	-	405	WP_005649049.1	type II toxin-antitoxin system VapC family toxin	Toxin
CH628_RS04350	815557..815793	-	237	WP_005649046.1	antitoxin	Antitoxin
CH628_RS04355	815886..816611	-	726	WP_105892704.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
CH628_RS04360	816664..817182	-	519	WP_005649040.1	isoprenylcysteine carboxyl methyltransferase family protein	-
CH628_RS04365	817401..819167	+	1767	WP_011271986.1	aspartate--tRNA ligase	-
CH628_RS04370	819189..819662	+	474	WP_011271985.1	dihydroneopterin triphosphate diphosphatase	-
CH628_RS04375	819674..820414	+	741	WP_005649034.1	YebC/PmpR family DNA-binding transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (6-44)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15692.29 Da
• Isoelectric Point: 8.9777

>T109784 WP_005649049.1 NZ_CP031681:c815560-815156 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIIAERVSQLLPNDRLVMSFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Nucleotide

• Length: 405 bp

>T109784 NZ_CP031681:c815560-815156 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTATTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATGAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTGAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGCGACCTATCGGAAATAATGATCTATGGATCGCTTGTCACGCATT
GAGTTTAAATGCCGTTCTTATTACACATAATGTAAAAGAATTTCAGCGAATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9037.19 Da
• Isoelectric Point: 4.2342

>AT109784 WP_005649046.1 NZ_CP031681:c815793-815557 [Haemophilus influenzae]
MLTKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Nucleotide

• Length: 237 bp

>AT109784 NZ_CP031681:c815793-815557 [Haemophilus influenzae]
ATGCTTACTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Structures

Toxin

• AlphaFold DB: E4QWH2

Antitoxin

• AlphaFold DB: E4QWH3