109781

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 46358..46989 Replicon chromosome
Accession NZ_CP031681
Organism Haemophilus influenzae strain P669-6977

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag CH628_RS00235 Protein ID WP_005651560.1
Coordinates 46591..46989 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag CH628_RS00230 Protein ID WP_005648011.1
Coordinates 46358..46591 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH628_RS00205 41834..43036 - 1203 WP_011272308.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
CH628_RS00210 43199..43868 + 670 Protein_38 DNA repair protein RadC -
CH628_RS00215 44082..44318 + 237 WP_005542826.1 50S ribosomal protein L28 -
CH628_RS00220 44330..44500 + 171 WP_005613503.1 50S ribosomal protein L33 -
CH628_RS00225 44847..46211 + 1365 WP_005651563.1 diaminobutyrate--2-oxoglutarate transaminase -
CH628_RS00230 46358..46591 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
CH628_RS00235 46591..46989 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
CH628_RS00240 47009..48544 + 1536 WP_011272306.1 L-2,4-diaminobutyrate decarboxylase -
CH628_RS00245 48986..49249 + 264 WP_032823788.1 hypothetical protein -
CH628_RS00250 49289..50134 - 846 WP_105886752.1 hypothetical protein -
CH628_RS00255 50196..50315 - 120 WP_005641687.1 Com family DNA-binding transcriptional regulator -
CH628_RS00260 50491..50979 - 489 WP_105872519.1 enoyl-CoA hydratase -
CH628_RS00265 50972..51598 - 627 WP_116947972.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T109781 WP_005651560.1 NZ_CP031681:46591-46989 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T109781 NZ_CP031681:46591-46989 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCTGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT109781 WP_005648011.1 NZ_CP031681:46358-46591 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT109781 NZ_CP031681:46358-46591 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References