109779

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 585021..585499 Replicon chromosome
Accession NZ_CP031680
Organism Haemophilus influenzae strain P672-7661

Toxin (Protein)


Gene name VapD Uniprot ID A0A0H3PEZ5
Locus tag CH631_RS02920 Protein ID WP_005656500.1
Coordinates 585221..585499 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag CH631_RS02915 Protein ID WP_005649350.1
Coordinates 585021..585212 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH631_RS02890 580600..581232 + 633 WP_162628607.1 dTMP kinase -
CH631_RS02895 581229..582212 + 984 WP_105894578.1 DNA polymerase III subunit delta' -
CH631_RS02900 582267..583049 + 783 WP_105894579.1 YchF/TatD family DNA exonuclease -
CH631_RS02905 583076..583600 + 525 WP_005652096.1 DUF1523 family protein -
CH631_RS02910 583651..584949 + 1299 WP_005691371.1 hemolysin family protein -
CH631_RS02915 585021..585212 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
CH631_RS02920 585221..585499 + 279 WP_005656500.1 virulence-associated protein VapD Toxin
CH631_RS02925 585592..586122 + 531 WP_162877158.1 hypothetical protein -
CH631_RS02930 586194..587693 + 1500 WP_116939815.1 fused PTS fructose transporter subunit IIA/HPr protein -
CH631_RS02935 587695..588636 + 942 WP_105894582.1 1-phosphofructokinase -
CH631_RS02940 588638..590308 + 1671 WP_105894583.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.09 Da        Isoelectric Point: 5.7408

>T109779 WP_005656500.1 NZ_CP031680:585221-585499 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T109779 NZ_CP031680:585221-585499 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAACAGGCTTATACAGA
CATTGGCGCAGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAACATGAATGAAGATATGGCGA
ATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGCGCTTTTCGTATT
GAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT109779 WP_005649350.1 NZ_CP031680:585021-585212 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT109779 NZ_CP031680:585021-585212 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTACCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGATTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3PEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References