Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 45569..46200 Replicon chromosome
Accession NZ_CP031680
Organism Haemophilus influenzae strain P672-7661

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag CH631_RS00225 Protein ID WP_005651560.1
Coordinates 45802..46200 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag CH631_RS00220 Protein ID WP_005648011.1
Coordinates 45569..45802 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH631_RS00195 41048..42250 - 1203 WP_105894712.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
CH631_RS00200 42414..43078 + 665 Protein_38 DNA repair protein RadC -
CH631_RS00205 43292..43528 + 237 WP_005542826.1 50S ribosomal protein L28 -
CH631_RS00210 43540..43710 + 171 WP_005613503.1 50S ribosomal protein L33 -
CH631_RS00215 44058..45422 + 1365 WP_074039351.1 diaminobutyrate--2-oxoglutarate transaminase -
CH631_RS00220 45569..45802 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
CH631_RS00225 45802..46200 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
CH631_RS00230 46220..47755 + 1536 WP_105894714.1 L-2,4-diaminobutyrate decarboxylase -
CH631_RS00235 47988..48803 + 816 WP_005648023.1 DNA-formamidopyrimidine glycosylase -
CH631_RS00240 48877..49896 - 1020 WP_105894715.1 outer membrane-stress sensor serine endopeptidase DegS -
CH631_RS00245 49897..51015 - 1119 WP_105894716.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T109777 WP_005651560.1 NZ_CP031680:45802-46200 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T109777 NZ_CP031680:45802-46200 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCGGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT109777 WP_005648011.1 NZ_CP031680:45569-45802 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT109777 NZ_CP031680:45569-45802 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References