Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 576639..577117 Replicon chromosome
Accession NZ_CP031679
Organism Haemophilus influenzae strain P676-2514

Toxin (Protein)


Gene name VapD Uniprot ID Q4QN95
Locus tag CH635_RS02915 Protein ID WP_011272058.1
Coordinates 576839..577117 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q4QN94
Locus tag CH635_RS02910 Protein ID WP_011272059.1
Coordinates 576639..576830 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH635_RS02890 572849..573832 + 984 WP_038440579.1 DNA polymerase III subunit delta' -
CH635_RS02895 573885..574667 + 783 WP_038440581.1 YchF/TatD family DNA exonuclease -
CH635_RS02900 574694..575218 + 525 WP_038440582.1 DUF1523 family protein -
CH635_RS02905 575269..576567 + 1299 WP_005691371.1 hemolysin family protein -
CH635_RS02910 576639..576830 + 192 WP_011272059.1 DUF5397 family protein Antitoxin
CH635_RS02915 576839..577117 + 279 WP_011272058.1 virulence-associated protein VapD Toxin
CH635_RS02920 577210..577740 + 531 WP_038440586.1 hypothetical protein -
CH635_RS02925 577812..579311 + 1500 WP_011272056.1 fused PTS fructose transporter subunit IIA/HPr protein -
CH635_RS02930 579313..580254 + 942 WP_011272055.1 1-phosphofructokinase -
CH635_RS02935 580256..581926 + 1671 WP_011272054.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10647.08 Da        Isoelectric Point: 4.9670

>T109772 WP_011272058.1 NZ_CP031679:576839-577117 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T109772 NZ_CP031679:576839-577117 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTGGCGCAGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAACATGAATGAAGATATGGCGA
ATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGCGCTTTTCGTATT
GAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7073.06 Da        Isoelectric Point: 3.8431

>AT109772 WP_011272059.1 NZ_CP031679:576639-576830 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSYLLEDPEAE

Download         Length: 192 bp

>AT109772 NZ_CP031679:576639-576830 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGCTTAT
CTTACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6ZI0
PDB 6ZN8
PDB 6ZI1

Antitoxin

Source ID Structure
PDB 6ZN8
AlphaFold DB Q4QN94

References