Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 746522..747159 Replicon chromosome
Accession NZ_CP031678
Organism Haemophilus influenzae strain P679-2791

Toxin (Protein)


Gene name VapC1 Uniprot ID -
Locus tag CH639_RS03880 Protein ID WP_084999833.1
Coordinates 746522..746926 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag CH639_RS03885 Protein ID WP_044332438.1
Coordinates 746923..747159 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH639_RS03850 742084..742650 + 567 WP_005544066.1 elongation factor P -
CH639_RS03860 743002..743586 - 585 WP_050847300.1 primosomal replication protein -
CH639_RS03865 743619..744971 - 1353 WP_084999837.1 Na+/H+ antiporter family protein -
CH639_RS03870 745285..745974 - 690 WP_005686760.1 ribonuclease T -
CH639_RS03875 746048..746455 - 408 WP_105883398.1 lactoylglutathione lyase -
CH639_RS03880 746522..746926 - 405 WP_084999833.1 type II toxin-antitoxin system VapC family toxin Toxin
CH639_RS03885 746923..747159 - 237 WP_044332438.1 antitoxin Antitoxin
CH639_RS03890 747252..747977 - 726 WP_005662952.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
CH639_RS03895 748030..748548 - 519 WP_005662954.1 isoprenylcysteine carboxyl methyltransferase family protein -
CH639_RS03900 748768..750534 + 1767 WP_084999831.1 aspartate--tRNA ligase -
CH639_RS03905 750556..751029 + 474 WP_162626781.1 dihydroneopterin triphosphate diphosphatase -
CH639_RS03910 751042..751782 + 741 WP_005662961.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15692.25 Da        Isoelectric Point: 8.4660

>T109766 WP_084999833.1 NZ_CP031678:c746926-746522 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPQIVAERVSQLLPNDRLVMSFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNIKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T109766 NZ_CP031678:c746926-746522 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCCAAATTGTTGCTGAACGAGTATCACA
ATTATTACCTAACGATCGCTTAGTTATGAGCTTTATTACTTATGCTGAACTTATTAAAGGTGCGTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTGAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGCGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATATAAAAGAGTTTCAGCGTATTACAGATCTTCAATGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8977.08 Da        Isoelectric Point: 4.2220

>AT109766 WP_044332438.1 NZ_CP031678:c747159-746923 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPVDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFDGFDESFIQTLEARDDLPPQERENL

Download         Length: 237 bp

>AT109766 NZ_CP031678:c747159-746923 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCAGTGGACTTTCGTTTTGATGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGAGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTGTTTG
ATGGATTTGATGAAAGTTTTATTCAAACACTTGAAGCCCGTGATGATTTACCGCCTCAAGAACGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References