Detailed information of TA system TA109763

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 378259..378769
• Replicon: chromosome
• Accession: NZ_CP031678
• Organism: Haemophilus influenzae strain P679-2791

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A0H3PB74
• Locus tag: CH639_RS01895
• Protein ID: WP_005658624.1
• Coordinates: 378259..378480 (+)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: CH639_RS01900
• Protein ID: WP_005650837.1
• Coordinates: 378473..378769 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH639_RS01875	374185..374349	-	165	WP_032823763.1	hypothetical protein	-
CH639_RS01880	374402..374566	-	165	WP_105883420.1	ABC transporter	-
CH639_RS01885	374578..374781	-	204	WP_105883412.1	ABC transporter	-
CH639_RS01890	375097..378152	+	3056	Protein_349	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
CH639_RS01895	378259..378480	+	222	WP_005658624.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CH639_RS01900	378473..378769	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
CH639_RS01905	378936..380852	+	1917	WP_116956868.1	ABC transporter ATP-binding protein	-
CH639_RS01910	380862..381410	+	549	WP_050829194.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
CH639_RS01915	381426..381977	+	552	WP_084999963.1	Sua5/YciO/YrdC/YwlC family protein	-
CH639_RS01920	381981..382787	+	807	WP_011272150.1	shikimate dehydrogenase	-
CH639_RS01925	382799..383551	+	753	WP_011272149.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (10-63)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8834.35 Da
• Isoelectric Point: 10.7588

>T109763 WP_005658624.1 NZ_CP031678:378259-378480 [Haemophilus influenzae]
VQNLLENQALFAILDGEIWELRPIRDRILFARLMDGRFVLLHQFMKKTQKTPKREIQTTQQRLSELKERLKNE

Nucleotide

• Length: 222 bp

>T109763 NZ_CP031678:378259-378480 [Haemophilus influenzae]
GTGCAAAATCTCCTTGAAAATCAAGCTCTTTTTGCTATTTTAGACGGTGAAATTTGGGAACTTCGTCCAATTAGGGATCG
CATCTTGTTTGCAAGATTAATGGACGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAAC
GAGAAATCCAAACTACCCAACAACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT109763 WP_005650837.1 NZ_CP031678:378473-378769 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT109763 NZ_CP031678:378473-378769 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAACAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTATTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A0H3PB74