Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 46598..47229 Replicon chromosome
Accession NZ_CP031678
Organism Haemophilus influenzae strain P679-2791

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag CH639_RS00240 Protein ID WP_005651560.1
Coordinates 46831..47229 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag CH639_RS00235 Protein ID WP_005648011.1
Coordinates 46598..46831 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH639_RS00210 42079..43281 - 1203 WP_011272308.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
CH639_RS00215 43444..44109 + 666 WP_013526173.1 DNA repair protein RadC -
CH639_RS00220 44323..44559 + 237 WP_005542826.1 50S ribosomal protein L28 -
CH639_RS00225 44571..44741 + 171 WP_005613503.1 50S ribosomal protein L33 -
CH639_RS00230 45087..46451 + 1365 WP_005651563.1 diaminobutyrate--2-oxoglutarate transaminase -
CH639_RS00235 46598..46831 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
CH639_RS00240 46831..47229 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
CH639_RS00245 47249..48784 + 1536 WP_011272306.1 L-2,4-diaminobutyrate decarboxylase -
CH639_RS00250 49016..49831 + 816 WP_011272305.1 DNA-formamidopyrimidine glycosylase -
CH639_RS00255 49905..50927 - 1023 WP_005693292.1 outer membrane-stress sensor serine endopeptidase DegS -
CH639_RS00260 50928..52046 - 1119 WP_011272304.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T109761 WP_005651560.1 NZ_CP031678:46831-47229 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T109761 NZ_CP031678:46831-47229 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCTGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT109761 WP_005648011.1 NZ_CP031678:46598-46831 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT109761 NZ_CP031678:46598-46831 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References