Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2085889..2086366 Replicon chromosome
Accession NZ_CP031673
Organism Staphylococcus aureus strain MOZ66

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag DD548_RS11000 Protein ID WP_000052078.1
Coordinates 2086178..2086366 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag DD548_RS10995 Protein ID WP_001059690.1
Coordinates 2085889..2086149 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD548_RS10960 2081282..2081998 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
DD548_RS10965 2082146..2082568 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
DD548_RS10970 2082967..2083461 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
DD548_RS10975 2083616..2084233 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
DD548_RS10980 2084306..2084887 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
DD548_RS10985 2085112..2085348 + 237 WP_000368687.1 hypothetical protein -
DD548_RS10990 2085345..2085548 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
DD548_RS10995 2085889..2086149 + 261 WP_001059690.1 hypothetical protein Antitoxin
DD548_RS11000 2086178..2086366 + 189 WP_000052078.1 hypothetical protein Toxin
DD548_RS11005 2086554..2087123 + 570 WP_001106654.1 hypothetical protein -
DD548_RS11010 2087211..2087495 + 285 WP_001004395.1 hypothetical protein -
DD548_RS11015 2087557..2087775 + 219 WP_000005886.1 hypothetical protein -
DD548_RS11020 2088271..2088471 - 201 WP_001059082.1 cold-shock protein -
DD548_RS11025 2088828..2089514 - 687 WP_001548082.1 thermonuclease family protein -
DD548_RS11030 2089855..2090325 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-137)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T109753 WP_000052078.1 NZ_CP031673:2086178-2086366 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T109753 NZ_CP031673:2086178-2086366 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT109753 WP_001059690.1 NZ_CP031673:2085889-2086149 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT109753 NZ_CP031673:2085889-2086149 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References