Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 834706..835183 Replicon chromosome
Accession NZ_CP031670
Organism Staphylococcus aureus strain 64

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag DD547_RS04195 Protein ID WP_000052078.1
Coordinates 834706..834894 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag DD547_RS04200 Protein ID WP_001059690.1
Coordinates 834923..835183 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD547_RS04165 830747..831217 + 471 WP_000824472.1 hypothetical protein -
DD547_RS04170 831558..832244 + 687 WP_001548082.1 thermonuclease family protein -
DD547_RS04175 832601..832801 + 201 WP_001059082.1 cold-shock protein -
DD547_RS04180 833297..833515 - 219 WP_000005886.1 hypothetical protein -
DD547_RS04185 833577..833861 - 285 WP_001004395.1 hypothetical protein -
DD547_RS04190 833949..834518 - 570 WP_050956526.1 hypothetical protein -
DD547_RS04195 834706..834894 - 189 WP_000052078.1 hypothetical protein Toxin
DD547_RS04200 834923..835183 - 261 WP_001059690.1 hypothetical protein Antitoxin
DD547_RS04205 835524..835727 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
DD547_RS04210 835724..835960 - 237 WP_000368687.1 hypothetical protein -
DD547_RS04215 836185..836766 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
DD547_RS04220 836839..837456 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
DD547_RS04225 837611..838105 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
DD547_RS04230 838504..838926 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
DD547_RS04235 839074..839790 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T109718 WP_000052078.1 NZ_CP031670:c834894-834706 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T109718 NZ_CP031670:c834894-834706 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT109718 WP_001059690.1 NZ_CP031670:c835183-834923 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT109718 NZ_CP031670:c835183-834923 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References