Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2158422..2158936 Replicon chromosome
Accession NZ_CP031664
Organism Staphylococcus aureus strain 28

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag DD545_RS11280 Protein ID WP_000581792.1
Coordinates 2158422..2158631 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag DD545_RS11285 Protein ID WP_000138932.1
Coordinates 2158643..2158936 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD545_RS11260 2153930..2155288 - 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
DD545_RS11265 2155303..2156373 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
DD545_RS11270 2156691..2157893 + 1203 WP_001109939.1 rod shape-determining protein RodA -
DD545_RS11275 2158157..2158294 - 138 WP_000828354.1 hypothetical protein -
DD545_RS11280 2158422..2158631 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
DD545_RS11285 2158643..2158936 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
DD545_RS11290 2159102..2160586 + 1485 WP_000571549.1 cardiolipin synthase -
DD545_RS11295 2160614..2161261 + 648 WP_001187629.1 HD domain-containing protein -
DD545_RS11315 2161974..2162846 - 873 WP_000725802.1 membrane protein insertase YidC -
DD545_RS11320 2162932..2163573 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T109693 WP_000581792.1 NZ_CP031664:c2158631-2158422 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T109693 NZ_CP031664:c2158631-2158422 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT109693 WP_000138932.1 NZ_CP031664:c2158936-2158643 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT109693 NZ_CP031664:c2158936-2158643 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References