Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2138665..2139194 Replicon chromosome
Accession NZ_CP031664
Organism Staphylococcus aureus strain 28

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DD545_RS11190 Protein ID WP_000621175.1
Coordinates 2138665..2139027 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DD545_RS11195 Protein ID WP_000948331.1
Coordinates 2139024..2139194 (-) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD545_RS11165 2135643..2136413 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
DD545_RS11170 2136388..2136867 - 480 WP_001190829.1 anti-sigma B factor RsbW -
DD545_RS11175 2136869..2137195 - 327 WP_001052491.1 anti-sigma factor antagonist -
DD545_RS11180 2137314..2138315 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DD545_RS11190 2138665..2139027 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DD545_RS11195 2139024..2139194 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DD545_RS11200 2139279..2140427 - 1149 WP_001281145.1 alanine racemase -
DD545_RS11205 2140493..2140852 - 360 WP_000581200.1 holo-ACP synthase -
DD545_RS11210 2140856..2141347 - 492 WP_001205910.1 PH domain-containing protein -
DD545_RS11215 2141334..2142917 - 1584 WP_001294626.1 PH domain-containing protein -
DD545_RS11220 2142910..2143389 - 480 WP_001287088.1 hypothetical protein -
DD545_RS11225 2143598..2144158 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-110)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T109692 WP_000621175.1 NZ_CP031664:c2139027-2138665 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T109692 NZ_CP031664:c2139027-2138665 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT109692 WP_000948331.1 NZ_CP031664:c2139194-2139024 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT109692 NZ_CP031664:c2139194-2139024 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References