Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 816838..817315 Replicon chromosome
Accession NZ_CP031664
Organism Staphylococcus aureus strain 28

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag DD545_RS04070 Protein ID WP_000052078.1
Coordinates 816838..817026 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag DD545_RS04075 Protein ID WP_001059690.1
Coordinates 817055..817315 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD545_RS04040 812879..813349 + 471 WP_000824472.1 hypothetical protein -
DD545_RS04045 813690..814376 + 687 WP_001548082.1 thermonuclease family protein -
DD545_RS04050 814733..814933 + 201 WP_001059082.1 cold-shock protein -
DD545_RS04055 815429..815647 - 219 WP_000005886.1 hypothetical protein -
DD545_RS04060 815709..815993 - 285 WP_001004395.1 hypothetical protein -
DD545_RS04065 816081..816650 - 570 WP_001106654.1 hypothetical protein -
DD545_RS04070 816838..817026 - 189 WP_000052078.1 hypothetical protein Toxin
DD545_RS04075 817055..817315 - 261 WP_001059690.1 hypothetical protein Antitoxin
DD545_RS04080 817656..817859 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
DD545_RS04085 817856..818092 - 237 WP_000368687.1 hypothetical protein -
DD545_RS04090 818317..818898 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
DD545_RS04095 818971..819588 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
DD545_RS04100 819743..820237 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
DD545_RS04105 820636..821058 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
DD545_RS04110 821206..821922 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T109680 WP_000052078.1 NZ_CP031664:c817026-816838 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T109680 NZ_CP031664:c817026-816838 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT109680 WP_001059690.1 NZ_CP031664:c817315-817055 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT109680 NZ_CP031664:c817315-817055 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References