109654

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 140918..141423 Replicon chromosome
Accession NZ_CP031660
Organism Pseudomonas aeruginosa strain PABL017

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag DZ899_RS00635 Protein ID WP_003121619.1
Coordinates 140918..141199 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag DZ899_RS00640 Protein ID WP_003112628.1
Coordinates 141196..141423 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZ899_RS00610 136169..137518 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
DZ899_RS00615 137567..138253 + 687 WP_003083762.1 FadR family transcriptional regulator -
DZ899_RS00620 138354..139088 + 735 WP_003117208.1 GntR family transcriptional regulator -
DZ899_RS00625 139292..139678 + 387 WP_014602345.1 aegerolysin family protein -
DZ899_RS00630 139710..140618 - 909 WP_003083769.1 LysR family transcriptional regulator -
DZ899_RS00635 140918..141199 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
DZ899_RS00640 141196..141423 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
DZ899_RS00645 141599..142219 - 621 WP_003101226.1 hypothetical protein -
DZ899_RS00650 142320..142820 + 501 WP_003101228.1 LEA type 2 family protein -
DZ899_RS00655 142893..143234 + 342 WP_003101229.1 alkylphosphonate utilization protein -
DZ899_RS00660 143316..144743 - 1428 WP_003083784.1 GABA permease -
DZ899_RS00665 144912..146405 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T109654 WP_003121619.1 NZ_CP031660:c141199-140918 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T109654 NZ_CP031660:c141199-140918 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT109654 WP_003112628.1 NZ_CP031660:c141423-141196 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT109654 NZ_CP031660:c141423-141196 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References