Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2927611..2928455 Replicon chromosome
Accession NZ_CP031653
Organism Escherichia coli strain UK_Dog_Liverpool

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag DL545_RS15230 Protein ID WP_000854686.1
Coordinates 2927611..2927994 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag DL545_RS15235 Protein ID WP_001285602.1
Coordinates 2928075..2928455 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DL545_RS15190 2922614..2923105 - 492 WP_001297187.1 DUF1097 domain-containing protein -
DL545_RS15195 2923207..2923761 - 555 WP_001001902.1 molecular chaperone YcdY -
DL545_RS15200 2923785..2924522 - 738 WP_000283664.1 zinc-binding phosphatase -
DL545_RS15205 2924577..2925515 - 939 WP_000351311.1 glyoxylate/hydroxypyruvate reductase GhrA -
DL545_RS15215 2925986..2926827 - 842 Protein_2792 DUF4942 domain-containing protein -
DL545_RS15220 2926912..2927109 - 198 WP_000839253.1 DUF957 domain-containing protein -
DL545_RS15225 2927126..2927614 - 489 WP_032180032.1 hypothetical protein -
DL545_RS15230 2927611..2927994 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
DL545_RS15235 2928075..2928455 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DL545_RS15240 2928466..2929149 - 684 WP_000086768.1 hypothetical protein -
DL545_RS15245 2929168..2929389 - 222 WP_000692298.1 DUF987 domain-containing protein -
DL545_RS15250 2929452..2929928 - 477 WP_001186726.1 RadC family protein -
DL545_RS15255 2929944..2930429 - 486 WP_000214307.1 antirestriction protein -
DL545_RS15260 2930521..2931342 - 822 WP_001761104.1 DUF945 domain-containing protein -
DL545_RS15270 2931443..2931651 - 209 Protein_2802 DUF905 domain-containing protein -
DL545_RS15275 2931752..2932207 - 456 WP_000581506.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgB / csgD / csgE / csgF / csgG 2918996..2971376 52380


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T109640 WP_000854686.1 NZ_CP031653:c2927994-2927611 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T109640 NZ_CP031653:c2927994-2927611 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT109640 WP_001285602.1 NZ_CP031653:c2928455-2928075 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT109640 NZ_CP031653:c2928455-2928075 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References