Detailed information of TA system TA109612

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 31127..31653
• Replicon: plasmid unnamed2
• Accession: NZ_CP031651
• Organism: Pantoea agglomerans strain TH81

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D0A61_RS22000
• Protein ID: WP_122459952.1
• Coordinates: 31127..31414 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8X8DPB7
• Locus tag: D0A61_RS22005
• Protein ID: WP_010257033.1
• Coordinates: 31414..31653 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0A61_RS21975	27027..28052	-	1026	WP_122459950.1	alpha/beta hydrolase	-
D0A61_RS21980	28121..29314	-	1194	WP_199740670.1	MFS transporter	-
D0A61_RS21985	29448..30344	+	897	WP_010257019.1	LysR family transcriptional regulator	-
D0A61_RS21990	30408..30584	-	177	WP_010257023.1	stress-induced protein	-
D0A61_RS21995	30786..31082	+	297	WP_033770131.1	hypothetical protein	-
D0A61_RS22000	31127..31414	-	288	WP_122459952.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D0A61_RS22005	31414..31653	-	240	WP_010257033.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
D0A61_RS22010	32013..33986	+	1974	WP_122459953.1	FIST C-terminal domain-containing protein	-
D0A61_RS22015	34090..35106	+	1017	WP_010257039.1	NAD(P)-dependent alcohol dehydrogenase	-
D0A61_RS22020	35156..35824	-	669	WP_122459954.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..182169	182169

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-77)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10998.88 Da
• Isoelectric Point: 10.2573

>T109612 WP_122459952.1 NZ_CP031651:c31414-31127 [Pantoea agglomerans]
MTWQLEFDQRALKEWRKLGPTVREQLKKKLAECLESPRIEANKLSGIPDCYKIKLKSSGYRLVYQVIDDRVVVFVVAVGK
RERSEVCSAASRRLS

Nucleotide

• Length: 288 bp

>T109612 NZ_CP031651:c31414-31127 [Pantoea agglomerans]
ATGACCTGGCAACTGGAGTTCGATCAGAGGGCACTGAAAGAGTGGCGCAAGCTGGGCCCGACAGTACGTGAACAGCTTAA
AAAGAAGCTGGCTGAGTGTCTTGAGTCACCCAGAATTGAGGCGAACAAACTCAGCGGGATACCTGACTGCTATAAGATCA
AGCTAAAGTCATCCGGTTATCGACTTGTATACCAGGTTATTGATGACCGGGTGGTGGTTTTTGTGGTGGCTGTCGGGAAA
AGAGAGCGCTCAGAGGTCTGTTCTGCCGCCTCCAGGCGTCTCTCTTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9002.33 Da
• Isoelectric Point: 4.3410

>AT109612 WP_010257033.1 NZ_CP031651:c31653-31414 [Pantoea agglomerans]
MGTINIRIDDDLKTRSYAALEKMGVTPSDALRLMLEYIADNERLPFKQTLLSDEDAALVDIVKERLRNPEPVRVTLDDL

Nucleotide

• Length: 240 bp

>AT109612 NZ_CP031651:c31653-31414 [Pantoea agglomerans]
ATGGGCACAATTAACATTCGAATCGATGATGACCTGAAGACACGATCCTATGCTGCGCTCGAAAAAATGGGTGTGACTCC
CTCTGATGCGCTGCGCCTGATGCTTGAATATATTGCAGATAATGAACGTCTTCCTTTTAAGCAAACGTTACTCAGTGACG
AAGATGCGGCGTTAGTAGACATAGTTAAAGAACGCCTGCGAAACCCTGAGCCTGTCCGGGTCACACTGGATGACCTTTAA