Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2351209..2351793 Replicon chromosome
Accession NZ_CP031649
Organism Pantoea agglomerans strain TH81

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag D0A61_RS11040 Protein ID WP_111533731.1
Coordinates 2351458..2351793 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag D0A61_RS11035 Protein ID WP_010245791.1
Coordinates 2351209..2351457 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0A61_RS11015 2347444..2348055 - 612 WP_010245779.1 DUF2291 domain-containing protein -
D0A61_RS11020 2348101..2349036 - 936 WP_010670004.1 D-ribose ABC transporter substrate-binding protein -
D0A61_RS11025 2349092..2349889 - 798 WP_033771597.1 D-threitol dehydrogenase -
D0A61_RS11030 2350242..2351054 + 813 WP_010245789.1 DeoR/GlpR family DNA-binding transcription regulator -
D0A61_RS11035 2351209..2351457 + 249 WP_010245791.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
D0A61_RS11040 2351458..2351793 + 336 WP_111533731.1 endoribonuclease MazF Toxin
D0A61_RS11045 2352094..2352480 + 387 WP_022625774.1 hypothetical protein -
D0A61_RS11050 2353090..2353929 - 840 WP_010670001.1 uroporphyrinogen-III C-methyltransferase -
D0A61_RS11055 2353929..2356546 - 2618 Protein_2132 nitrate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-108)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12020.02 Da        Isoelectric Point: 9.2246

>T109607 WP_111533731.1 NZ_CP031649:2351458-2351793 [Pantoea agglomerans]
MVSRFVPDAGDIIWVDFDPTKGSEQAGHRPAIVLSPFAYNNKTGMCLCVPCTTLSKGYPFEVPISAEKESVALSDQVKSI
AWKVRGATKKGVVSANELQQIRAKIKVIIGL

Download         Length: 336 bp

>T109607 NZ_CP031649:2351458-2351793 [Pantoea agglomerans]
ATGGTAAGCCGTTTTGTCCCTGATGCGGGAGATATCATCTGGGTGGATTTTGATCCGACCAAAGGCAGTGAGCAGGCAGG
TCACAGACCCGCTATTGTTCTTAGCCCGTTTGCTTACAATAACAAGACCGGCATGTGTCTCTGTGTCCCCTGCACCACCC
TGTCAAAGGGCTATCCGTTTGAAGTCCCCATAAGTGCTGAAAAAGAAAGCGTCGCCTTATCCGATCAAGTGAAAAGCATC
GCCTGGAAAGTCAGGGGAGCAACCAAAAAAGGCGTTGTTTCCGCAAACGAACTTCAGCAAATTCGCGCTAAGATAAAAGT
TATCATTGGCTTATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9271.61 Da        Isoelectric Point: 4.1826

>AT109607 WP_010245791.1 NZ_CP031649:2351209-2351457 [Pantoea agglomerans]
MIHGNVKRWGNSPAIRIPATLMQALNLNIDDEIKIDLVEGKLIIEPVKQEVGYSLEELLEGVTEENLHDPVEWGEPVGKE
IW

Download         Length: 249 bp

>AT109607 NZ_CP031649:2351209-2351457 [Pantoea agglomerans]
ATGATTCATGGAAATGTTAAACGCTGGGGTAACTCTCCGGCGATACGTATCCCGGCGACATTGATGCAGGCACTAAATCT
TAATATTGATGACGAAATTAAAATCGATTTAGTTGAAGGGAAACTCATTATCGAGCCTGTCAAACAGGAAGTGGGTTACT
CTCTTGAAGAACTGCTTGAAGGCGTGACAGAGGAAAATCTGCACGATCCAGTCGAATGGGGTGAACCTGTCGGGAAGGAG
ATTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References