Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2363030..2364005 Replicon chromosome
Accession NZ_CP031643
Organism Bacillus anthracis strain MCCC 1A01412

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A7U6C7L7
Locus tag DY471_RS12460 Protein ID WP_002021399.1
Coordinates 2363030..2363767 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID D8GY54
Locus tag DY471_RS12465 Protein ID WP_000594608.1
Coordinates 2363880..2364005 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DY471_RS12435 2358104..2358814 + 711 WP_071729146.1 class I SAM-dependent methyltransferase -
DY471_RS12440 2358934..2359341 + 408 WP_071729145.1 VOC family protein -
DY471_RS28855 2359448..2359540 + 93 Protein_2356 methyltransferase -
DY471_RS12445 2359662..2361347 - 1686 WP_071729144.1 alpha-keto acid decarboxylase family protein -
DY471_RS12450 2361454..2361936 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
DY471_RS12455 2362104..2362841 + 738 WP_071729143.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
DY471_RS12460 2363030..2363767 + 738 WP_002021399.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
DY471_RS12465 2363880..2364005 + 126 WP_000594608.1 hypothetical protein Antitoxin
DY471_RS28565 2364081..2364257 + 177 WP_000852625.1 hypothetical protein -
DY471_RS12470 2364301..2364576 - 276 WP_001041552.1 hypothetical protein -
DY471_RS12475 2364856..2365093 - 238 Protein_2364 hypothetical protein -
DY471_RS28570 2365423..2365599 + 177 WP_000808045.1 hypothetical protein -
DY471_RS12480 2365743..2367212 + 1470 WP_071729142.1 beta-Ala-His dipeptidase -
DY471_RS12485 2367793..2368263 - 471 WP_000771836.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28331.03 Da        Isoelectric Point: 8.2638

>T109597 WP_002021399.1 NZ_CP031643:2363030-2363767 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T109597 NZ_CP031643:2363030-2363767 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACAGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGCGGTATCCGTTCTCAATTTAGTACGATTATTCCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4878.27 Da        Isoelectric Point: 3.9507

>AT109597 WP_000594608.1 NZ_CP031643:2363880-2364005 [Bacillus anthracis]
VIKNNDNDFFKEDNEDTTDFSLIKGDTMQQVEDLEDELKRK

Download         Length: 126 bp

>AT109597 NZ_CP031643:2363880-2364005 [Bacillus anthracis]
GTGATAAAAAATAATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACGGATTTCTCGTTAATTAAAGGGGATAC
GATGCAGCAAGTAGAAGATTTAGAAGATGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U6C7L7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U6H9M7

References