Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel2-ATphRel2/DUF4065(antitoxin)
Location 1996564..1998047 Replicon chromosome
Accession NZ_CP031643
Organism Bacillus anthracis strain MCCC 1A01412

Toxin (Protein)


Gene name phRel2 Uniprot ID A0A7U6H962
Locus tag DY471_RS10570 Protein ID WP_071727149.1
Coordinates 1996564..1997295 (+) Length 244 a.a.

Antitoxin (Protein)


Gene name ATphRel2 Uniprot ID A0A7U6H9B4
Locus tag DY471_RS10575 Protein ID WP_071727150.1
Coordinates 1997298..1998047 (+) Length 250 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DY471_RS10515 1991998..1992195 + 198 WP_071729931.1 hypothetical protein -
DY471_RS10520 1992230..1992421 + 192 WP_000283199.1 hypothetical protein -
DY471_RS10525 1992441..1992986 + 546 WP_071729930.1 hypothetical protein -
DY471_RS28530 1993154..1993318 + 165 WP_071729566.1 hypothetical protein -
DY471_RS10530 1993348..1993620 - 273 WP_080489196.1 hypothetical protein -
DY471_RS10535 1993948..1994211 + 264 WP_071727142.1 hypothetical protein -
DY471_RS10545 1994307..1994486 + 180 WP_071727143.1 hypothetical protein -
DY471_RS10550 1994516..1994845 + 330 WP_071727144.1 permease -
DY471_RS10555 1994863..1994985 + 123 WP_071727145.1 DUF3983 domain-containing protein -
DY471_RS28535 1995101..1995271 + 171 WP_071727146.1 hypothetical protein -
DY471_RS10560 1995299..1995781 + 483 WP_071727147.1 ArpU family transcriptional regulator -
DY471_RS10565 1995781..1996323 + 543 WP_071727148.1 site-specific integrase -
DY471_RS10570 1996564..1997295 + 732 WP_071727149.1 hypothetical protein Toxin
DY471_RS10575 1997298..1998047 + 750 WP_071727150.1 DUF4065 domain-containing protein Antitoxin
DY471_RS10580 1998495..1998755 + 261 WP_071727151.1 hypothetical protein -
DY471_RS10585 1998739..1999029 + 291 WP_071727152.1 hypothetical protein -
DY471_RS10590 1999036..1999290 + 255 WP_071727153.1 hypothetical protein -
DY471_RS10595 1999280..1999657 + 378 WP_071727154.1 HNH endonuclease -
DY471_RS10600 1999787..2000290 + 504 WP_071727155.1 phage terminase small subunit P27 family -
DY471_RS10605 2000292..2001986 + 1695 WP_000621130.1 terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1979238..2023396 44158


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(108-219)

Antitoxin

Antitoxin SocA-like, Panacea domain

(113-225)


Sequences

Toxin        


Download         Length: 244 a.a.        Molecular weight: 29194.20 Da        Isoelectric Point: 8.2238

>T109596 WP_071727149.1 NZ_CP031643:1996564-1997295 [Bacillus anthracis]
MESLQLQSLRETKPYCYYNEIQQIIIEICHFHNEFSAAWIKKNQSSELEFLNFNKKQVRQVTDIIEEREVFFLKDKFNSL
IKSYMNELKPLTIDFEMEYKYEKFDFRSRGKQFDSIMNKLKYYRVGKQGNGVFGAFNLNKCLNDLFGIRIVIEDFDHNCK
RFYQLCEELRTKHKIRVMDSSKHGYKATHIYFHGESNQYFPWELQIWNANDCKSNDISHGIHKRAYTEWASIYKNSKEIE
GGA

Download         Length: 732 bp

>T109596 NZ_CP031643:1996564-1997295 [Bacillus anthracis]
TTGGAAAGCTTACAATTACAAAGTTTACGAGAAACTAAACCATATTGTTATTATAATGAGATACAACAGATTATCATTGA
AATTTGTCATTTTCATAATGAATTCTCAGCAGCGTGGATAAAAAAGAATCAGTCAAGCGAATTAGAATTTCTAAACTTTA
ATAAGAAACAAGTTAGACAAGTGACTGATATTATTGAAGAAAGAGAAGTATTCTTTCTGAAGGATAAATTTAATAGTCTT
ATAAAAAGCTATATGAATGAATTAAAGCCTTTAACAATAGATTTCGAGATGGAATATAAATATGAAAAGTTTGATTTTCG
GTCTCGTGGAAAACAATTTGATTCGATAATGAATAAATTAAAATATTACAGAGTTGGAAAACAAGGGAATGGAGTTTTTG
GAGCTTTTAATCTCAATAAATGCTTAAACGATCTTTTCGGTATTCGAATAGTGATTGAAGATTTTGACCATAATTGTAAG
AGGTTTTATCAATTATGTGAAGAATTGAGAACTAAACATAAAATACGTGTAATGGATTCGTCAAAGCATGGTTATAAAGC
GACTCACATATATTTTCATGGGGAAAGTAATCAGTATTTTCCTTGGGAGTTACAAATATGGAATGCAAATGATTGTAAAT
CAAATGACATTTCACATGGAATACATAAACGCGCATATACTGAATGGGCATCAATTTATAAGAATTCAAAAGAAATTGAG
GGAGGTGCTTAA

Antitoxin


Download         Length: 250 a.a.        Molecular weight: 28159.15 Da        Isoelectric Point: 6.4955

>AT109596 WP_071727150.1 NZ_CP031643:1997298-1998047 [Bacillus anthracis]
MAFHFIAVMSHYSHGGRIAWHYSAETRLDKEFIQSFFSRVERKCGEVQLGIHKLSTESTSWDSVVQKDSFFKDVYRTQDI
DTFIGMVIQDQELSPTDVSKFILSILPSSHLKLQKLLYFSYAEFLLQTGVKLFKEPLVAFKYGPVVESVFHKYKVHGSTV
IDSKEDETICYSTESLAITPSIMKVASSEHGDAAMACILKVLEKYGGYSAGDLVDKTHQAGGPWDRVFKPGANCEITDDL
IIQYHQVIH

Download         Length: 750 bp

>AT109596 NZ_CP031643:1997298-1998047 [Bacillus anthracis]
ATGGCTTTTCACTTTATCGCAGTTATGAGTCACTATTCGCATGGGGGACGAATTGCATGGCATTATTCTGCCGAAACTCG
ACTTGATAAAGAATTCATCCAAAGCTTCTTTAGTCGGGTAGAAAGAAAATGTGGAGAAGTACAATTAGGTATCCACAAAT
TATCGACAGAGTCTACTAGTTGGGATTCTGTAGTACAAAAGGATTCTTTCTTTAAAGATGTATATAGAACTCAGGATATC
GATACTTTTATTGGGATGGTTATTCAGGATCAGGAATTAAGTCCTACAGATGTTTCGAAATTTATACTATCAATTTTGCC
ATCTTCACATCTTAAGTTACAAAAATTGCTTTATTTTTCATATGCAGAATTCTTGTTACAAACAGGCGTTAAATTATTTA
AAGAGCCATTAGTAGCTTTTAAATATGGTCCTGTAGTTGAAAGTGTTTTTCATAAGTATAAAGTTCATGGCTCTACAGTA
ATTGATTCTAAAGAAGATGAGACAATTTGCTATTCAACAGAATCATTAGCTATTACACCTTCTATTATGAAAGTGGCATC
TTCAGAACATGGTGATGCAGCAATGGCGTGTATTTTAAAAGTATTAGAAAAGTACGGTGGATATAGCGCAGGAGATTTAG
TTGATAAGACACATCAAGCAGGTGGTCCTTGGGATAGAGTGTTTAAGCCGGGGGCTAATTGTGAAATTACTGATGATTTA
ATTATACAATATCATCAGGTGATTCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U6H962

Antitoxin

Source ID Structure
AlphaFold DB A0A7U6H9B4

References