Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2361043..2362018 Replicon chromosome
Accession NZ_CP031642
Organism Bacillus anthracis strain MCCC 1A02161

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A1J9UW25
Locus tag DY470_RS12505 Protein ID WP_071737747.1
Coordinates 2361043..2361780 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1J9W3Q2
Locus tag DY470_RS12510 Protein ID WP_000594606.1
Coordinates 2361893..2362018 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DY470_RS12475 2356534..2357235 + 702 WP_001991930.1 hypothetical protein -
DY470_RS12485 2357363..2358247 + 885 WP_071737738.1 hypothetical protein -
DY470_RS12490 2358557..2359360 - 804 Protein_2347 alpha-keto acid decarboxylase family protein -
DY470_RS12495 2359467..2359949 + 483 WP_000191909.1 MarR family winged helix-turn-helix transcriptional regulator -
DY470_RS12500 2360117..2360854 + 738 WP_062923164.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
DY470_RS12505 2361043..2361780 + 738 WP_071737747.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
DY470_RS12510 2361893..2362018 + 126 WP_000594606.1 hypothetical protein Antitoxin
DY470_RS27795 2362094..2362270 + 177 WP_000852625.1 hypothetical protein -
DY470_RS12515 2362314..2362589 - 276 WP_071737736.1 hypothetical protein -
DY470_RS12520 2362880..2363108 - 229 Protein_2354 hypothetical protein -
DY470_RS27800 2363438..2363614 + 177 WP_000808045.1 hypothetical protein -
DY470_RS12525 2363758..2365227 + 1470 WP_000287525.1 beta-Ala-His dipeptidase -
DY470_RS12530 2365813..2366281 - 469 Protein_2357 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28325.03 Da        Isoelectric Point: 8.2672

>T109594 WP_071737747.1 NZ_CP031642:2361043-2361780 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVLEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T109594 NZ_CP031642:2361043-2361780 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCGAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGTTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTACTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACTATCATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4860.23 Da        Isoelectric Point: 3.9507

>AT109594 WP_000594606.1 NZ_CP031642:2361893-2362018 [Bacillus anthracis]
VIKNNDNDFFKEDNEDTTDFSLIKGDTLQQVEDLEDELKRK

Download         Length: 126 bp

>AT109594 NZ_CP031642:2361893-2362018 [Bacillus anthracis]
GTGATAAAAAATAATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACGGATTTCTCGTTAATTAAAGGGGATAC
ATTACAGCAAGTAGAAGATTTAGAAGATGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J9UW25

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9W3Q2

References