Detailed information of TA system TA109592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1910964..1911450
• Replicon: chromosome
• Accession: NZ_CP031640
• Organism: Streptococcus pyogenes strain MGAS7888

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q48QR0
• Locus tag: DZL14_RS09645
• Protein ID: WP_014407961.1
• Coordinates: 1910964..1911233 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A660A1J7
• Locus tag: DZL14_RS09650
• Protein ID: WP_014407962.1
• Coordinates: 1911223..1911450 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZL14_RS09630	1906459..1907532	+	1074	WP_011285298.1	DUF4097 family beta strand repeat protein	-
DZL14_RS09635	1907649..1909922	-	2274	WP_021340697.1	YhgE/Pip domain-containing protein	-
DZL14_RS09640	1910057..1910590	+	534	WP_010922785.1	TetR/AcrR family transcriptional regulator	-
DZL14_RS09645	1910964..1911233	-	270	WP_014407961.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DZL14_RS09650	1911223..1911450	-	228	WP_014407962.1	hypothetical protein	Antitoxin
DZL14_RS09655	1911603..1911974	-	372	WP_011285302.1	DUF1492 domain-containing protein	-
DZL14_RS09660	1911964..1912311	-	348	WP_011285303.1	DUF1492 domain-containing protein	-
DZL14_RS09665	1912592..1912837	-	246	WP_011285304.1	hypothetical protein	-
DZL14_RS09670	1912812..1913087	-	276	WP_014407964.1	hypothetical protein	-
DZL14_RS09675	1913077..1913415	-	339	WP_030126557.1	replication protein	-
DZL14_RS09680	1913457..1913723	-	267	WP_011285307.1	hypothetical protein	-
DZL14_RS09685	1913720..1914508	-	789	WP_011285308.1	hypothetical protein	-
DZL14_RS10070	1914599..1914757	-	159	WP_011285309.1	hypothetical protein	-
DZL14_RS09690	1914771..1915016	-	246	WP_011285310.1	hypothetical protein	-
DZL14_RS09695	1915012..1915338	-	327	Protein_1809	hypothetical protein	-
DZL14_RS10075	1915340..1915513	-	174	WP_011285312.1	hypothetical protein	-
DZL14_RS09700	1915519..1915692	-	174	WP_000694580.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10497.50 Da
• Isoelectric Point: 10.5027

>T109592 WP_014407961.1 NZ_CP031640:c1911233-1910964 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Nucleotide

• Length: 270 bp

>T109592 NZ_CP031640:c1911233-1910964 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8641.63 Da
• Isoelectric Point: 3.9607

>AT109592 WP_014407962.1 NZ_CP031640:c1911450-1911223 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Nucleotide

• Length: 228 bp

>AT109592 NZ_CP031640:c1911450-1911223 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A660A202

Antitoxin

• AlphaFold DB: A0A660A1J7