Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1782338..1782824 Replicon chromosome
Accession NZ_CP031638
Organism Streptococcus pyogenes strain MGAS8347

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag DZM45_RS08865 Protein ID WP_014407961.1
Coordinates 1782338..1782607 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag DZM45_RS08870 Protein ID WP_014407962.1
Coordinates 1782597..1782824 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZM45_RS08850 1777833..1778906 + 1074 WP_011285298.1 DUF4097 family beta strand repeat protein -
DZM45_RS08855 1779023..1781296 - 2274 WP_021340697.1 YhgE/Pip domain-containing protein -
DZM45_RS08860 1781431..1781964 + 534 WP_010922785.1 TetR/AcrR family transcriptional regulator -
DZM45_RS08865 1782338..1782607 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DZM45_RS08870 1782597..1782824 - 228 WP_014407962.1 hypothetical protein Antitoxin
DZM45_RS08875 1782977..1783348 - 372 WP_011285302.1 DUF1492 domain-containing protein -
DZM45_RS08880 1783338..1783685 - 348 WP_011285303.1 DUF1492 domain-containing protein -
DZM45_RS08885 1783966..1784211 - 246 WP_011285304.1 hypothetical protein -
DZM45_RS08890 1784186..1784461 - 276 WP_014407964.1 hypothetical protein -
DZM45_RS08895 1784451..1784789 - 339 WP_030126557.1 replication protein -
DZM45_RS08900 1784831..1785097 - 267 WP_011285307.1 hypothetical protein -
DZM45_RS08905 1785094..1785882 - 789 WP_011285308.1 hypothetical protein -
DZM45_RS09260 1785973..1786131 - 159 WP_011285309.1 hypothetical protein -
DZM45_RS08910 1786145..1786390 - 246 WP_011285310.1 hypothetical protein -
DZM45_RS08915 1786386..1786712 - 327 Protein_1652 hypothetical protein -
DZM45_RS09265 1786714..1786887 - 174 WP_011285312.1 hypothetical protein -
DZM45_RS08920 1786893..1787066 - 174 WP_000694580.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T109590 WP_014407961.1 NZ_CP031638:c1782607-1782338 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T109590 NZ_CP031638:c1782607-1782338 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT109590 WP_014407962.1 NZ_CP031638:c1782824-1782597 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT109590 NZ_CP031638:c1782824-1782597 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References