Detailed information of TA system TA109589

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1885585..1886071
• Replicon: chromosome
• Accession: NZ_CP031637
• Organism: Streptococcus pyogenes strain MGAS10786

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q48QR0
• Locus tag: DZN22_RS09630
• Protein ID: WP_014407961.1
• Coordinates: 1885585..1885854 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A660A1J7
• Locus tag: DZN22_RS09635
• Protein ID: WP_014407962.1
• Coordinates: 1885844..1886071 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZN22_RS09615	1881080..1882153	+	1074	WP_011285298.1	DUF4097 family beta strand repeat protein	-
DZN22_RS09620	1882270..1884543	-	2274	WP_021340697.1	YhgE/Pip domain-containing protein	-
DZN22_RS09625	1884678..1885211	+	534	WP_010922785.1	TetR/AcrR family transcriptional regulator	-
DZN22_RS09630	1885585..1885854	-	270	WP_014407961.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DZN22_RS09635	1885844..1886071	-	228	WP_014407962.1	hypothetical protein	Antitoxin
DZN22_RS09640	1886224..1886595	-	372	WP_011285302.1	DUF1492 domain-containing protein	-
DZN22_RS09645	1886585..1886932	-	348	WP_011285303.1	DUF1492 domain-containing protein	-
DZN22_RS09650	1887213..1887458	-	246	WP_011285304.1	hypothetical protein	-
DZN22_RS09655	1887433..1887708	-	276	WP_014407964.1	hypothetical protein	-
DZN22_RS09660	1887698..1888036	-	339	WP_030126557.1	replication protein	-
DZN22_RS09665	1888078..1888344	-	267	WP_011285307.1	hypothetical protein	-
DZN22_RS09670	1888341..1889129	-	789	WP_011285308.1	hypothetical protein	-
DZN22_RS10060	1889220..1889378	-	159	WP_011285309.1	hypothetical protein	-
DZN22_RS09675	1889392..1889637	-	246	WP_011285310.1	hypothetical protein	-
DZN22_RS09680	1889633..1889959	-	327	Protein_1806	hypothetical protein	-
DZN22_RS10065	1889961..1890134	-	174	WP_011285312.1	hypothetical protein	-
DZN22_RS09685	1890140..1890313	-	174	WP_000694580.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10497.50 Da
• Isoelectric Point: 10.5027

>T109589 WP_014407961.1 NZ_CP031637:c1885854-1885585 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Nucleotide

• Length: 270 bp

>T109589 NZ_CP031637:c1885854-1885585 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8641.63 Da
• Isoelectric Point: 3.9607

>AT109589 WP_014407962.1 NZ_CP031637:c1886071-1885844 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Nucleotide

• Length: 228 bp

>AT109589 NZ_CP031637:c1886071-1885844 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A660A202

Antitoxin

• AlphaFold DB: A0A660A1J7