Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 1774745..1775231 | Replicon | chromosome |
Accession | NZ_CP031636 | ||
Organism | Streptococcus pyogenes strain MGAS10826 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q48QR0 |
Locus tag | DZN59_RS08940 | Protein ID | WP_014407961.1 |
Coordinates | 1774962..1775231 (+) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A660A1J7 |
Locus tag | DZN59_RS08935 | Protein ID | WP_014407962.1 |
Coordinates | 1774745..1774972 (+) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DZN59_RS08885 | 1770503..1770676 | + | 174 | WP_000694580.1 | hypothetical protein | - |
DZN59_RS09465 | 1770682..1770855 | + | 174 | WP_011285312.1 | hypothetical protein | - |
DZN59_RS08890 | 1770857..1771183 | + | 327 | Protein_1641 | hypothetical protein | - |
DZN59_RS08895 | 1771179..1771424 | + | 246 | WP_011285310.1 | hypothetical protein | - |
DZN59_RS09470 | 1771438..1771596 | + | 159 | WP_011285309.1 | hypothetical protein | - |
DZN59_RS08900 | 1771687..1772475 | + | 789 | WP_011285308.1 | hypothetical protein | - |
DZN59_RS08905 | 1772472..1772738 | + | 267 | WP_011285307.1 | hypothetical protein | - |
DZN59_RS08910 | 1772780..1773118 | + | 339 | WP_030126557.1 | replication protein | - |
DZN59_RS08915 | 1773108..1773383 | + | 276 | WP_014407964.1 | hypothetical protein | - |
DZN59_RS08920 | 1773358..1773603 | + | 246 | WP_011285304.1 | hypothetical protein | - |
DZN59_RS08925 | 1773884..1774231 | + | 348 | WP_011285303.1 | DUF1492 domain-containing protein | - |
DZN59_RS08930 | 1774221..1774592 | + | 372 | WP_011285302.1 | DUF1492 domain-containing protein | - |
DZN59_RS08935 | 1774745..1774972 | + | 228 | WP_014407962.1 | hypothetical protein | Antitoxin |
DZN59_RS08940 | 1774962..1775231 | + | 270 | WP_014407961.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
DZN59_RS08945 | 1775605..1776138 | - | 534 | WP_010922785.1 | TetR/AcrR family transcriptional regulator | - |
DZN59_RS08950 | 1776273..1778546 | + | 2274 | WP_021340697.1 | YhgE/Pip domain-containing protein | - |
DZN59_RS08955 | 1778663..1779736 | - | 1074 | WP_011285298.1 | DUF4097 family beta strand repeat protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10497.50 Da Isoelectric Point: 10.5027
>T109588 WP_014407961.1 NZ_CP031636:1774962-1775231 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR
Download Length: 270 bp
>T109588 NZ_CP031636:1774962-1775231 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG
Antitoxin
Download Length: 76 a.a. Molecular weight: 8641.63 Da Isoelectric Point: 3.9607
>AT109588 WP_014407962.1 NZ_CP031636:1774745-1774972 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL
Download Length: 228 bp
>AT109588 NZ_CP031636:1774745-1774972 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A660A202 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A660A1J7 |