Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1774745..1775231 Replicon chromosome
Accession NZ_CP031636
Organism Streptococcus pyogenes strain MGAS10826

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag DZN59_RS08940 Protein ID WP_014407961.1
Coordinates 1774962..1775231 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag DZN59_RS08935 Protein ID WP_014407962.1
Coordinates 1774745..1774972 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DZN59_RS08885 1770503..1770676 + 174 WP_000694580.1 hypothetical protein -
DZN59_RS09465 1770682..1770855 + 174 WP_011285312.1 hypothetical protein -
DZN59_RS08890 1770857..1771183 + 327 Protein_1641 hypothetical protein -
DZN59_RS08895 1771179..1771424 + 246 WP_011285310.1 hypothetical protein -
DZN59_RS09470 1771438..1771596 + 159 WP_011285309.1 hypothetical protein -
DZN59_RS08900 1771687..1772475 + 789 WP_011285308.1 hypothetical protein -
DZN59_RS08905 1772472..1772738 + 267 WP_011285307.1 hypothetical protein -
DZN59_RS08910 1772780..1773118 + 339 WP_030126557.1 replication protein -
DZN59_RS08915 1773108..1773383 + 276 WP_014407964.1 hypothetical protein -
DZN59_RS08920 1773358..1773603 + 246 WP_011285304.1 hypothetical protein -
DZN59_RS08925 1773884..1774231 + 348 WP_011285303.1 DUF1492 domain-containing protein -
DZN59_RS08930 1774221..1774592 + 372 WP_011285302.1 DUF1492 domain-containing protein -
DZN59_RS08935 1774745..1774972 + 228 WP_014407962.1 hypothetical protein Antitoxin
DZN59_RS08940 1774962..1775231 + 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DZN59_RS08945 1775605..1776138 - 534 WP_010922785.1 TetR/AcrR family transcriptional regulator -
DZN59_RS08950 1776273..1778546 + 2274 WP_021340697.1 YhgE/Pip domain-containing protein -
DZN59_RS08955 1778663..1779736 - 1074 WP_011285298.1 DUF4097 family beta strand repeat protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T109588 WP_014407961.1 NZ_CP031636:1774962-1775231 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T109588 NZ_CP031636:1774962-1775231 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT109588 WP_014407962.1 NZ_CP031636:1774745-1774972 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT109588 NZ_CP031636:1774745-1774972 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A660A202


Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References